Document Detail


Eosinophils in acute appendicitis: possible significance.
MedLine Citation:
PMID:  9444860     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
120 consecutive appendicectomies and 20 appendices from medicolegal autopsies were studied. The cases were grouped as. A: Acute appendicitis. B: Acute presentation, not diagnostic of acute appendicitis C: Elective appendicectomies D: Normal appendices from autopsies. Eosinophils and mast cells were counted in the muscularis, in Giemsa stained sections. The mean eosinophil and mast cell counts per mm2 were--A. 215.9; 26.5. B. 66.0; 32.1. C. 6.7; 25.8. D. 4.2; 19.6 respectively. Eosinophil count is significantly higher in A compared to others (p < 0.0001) and there was no range overlap with C and D. B is a heterogenous group with 37.5% having eosinophil counts in the range seen in A. Cases with mural eosinophil showed histological evidence of mast cell degranulation. Eosinophil infiltration of the muscularis is an early event universally seen in acute appendicitis. It is possible that the disease is triggered by Type I Hypersensitivity, and that infection is a later consequence.
Authors:
K P Aravindan
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Indian journal of pathology & microbiology     Volume:  40     ISSN:  0377-4929     ISO Abbreviation:  Indian J Pathol Microbiol     Publication Date:  1997 Oct 
Date Detail:
Created Date:  1998-02-27     Completed Date:  1998-02-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7605904     Medline TA:  Indian J Pathol Microbiol     Country:  INDIA    
Other Details:
Languages:  eng     Pagination:  491-8     Citation Subset:  IM    
Affiliation:
Department of Pathology, Medical College, Calicut.
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MeSH Terms
Descriptor/Qualifier:
Appendectomy*
Appendicitis / pathology*
Appendix / cytology*,  pathology
Autopsy
Eosinophils / cytology,  pathology*
Gangrene
Humans
Mast Cells / cytology,  pathology

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