Document Detail


Eosinophils: changing perspectives in health and disease.
MedLine Citation:
PMID:  23154224     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Eosinophils have been traditionally perceived as terminally differentiated cytotoxic effector cells. Recent studies have profoundly altered this simplistic view of eosinophils and their function. New insights into the molecular pathways that control the development, trafficking and degranulation of eosinophils have improved our understanding of the immunomodulatory functions of these cells and their roles in promoting homeostasis. Likewise, recent developments have generated a more sophisticated view of how eosinophils contribute to the pathogenesis of different diseases, including asthma and primary hypereosinophilic syndromes, and have also provided us with a more complete appreciation of the activities of these cells during parasitic infection.
Authors:
Helene F Rosenberg; Kimberly D Dyer; Paul S Foster
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't; Review     Date:  2012-11-16
Journal Detail:
Title:  Nature reviews. Immunology     Volume:  13     ISSN:  1474-1741     ISO Abbreviation:  Nat. Rev. Immunol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-21     Completed Date:  2013-02-20     Revised Date:  2014-01-10    
Medline Journal Info:
Nlm Unique ID:  101124169     Medline TA:  Nat Rev Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  9-22     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Asthma / etiology,  immunology
Cell Degranulation / immunology
Cytokines / immunology
Eosinophilia / etiology,  immunology
Eosinophils / immunology*,  ultrastructure
Humans
Hypereosinophilic Syndrome / etiology,  immunology
Leukocytes / immunology
Mice
Models, Immunological
Parasitic Diseases / immunology
Receptors, Immunologic / immunology
Grant Support
ID/Acronym/Agency:
AI000941/AI/NIAID NIH HHS; AI000943/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Cytokines; 0/Receptors, Immunologic
Comments/Corrections
Comment In:
Nat Rev Immunol. 2013 Dec;13(12):902   [PMID:  24270783 ]
Nat Rev Immunol. 2013 Dec;13(12):902   [PMID:  24270781 ]

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