Document Detail

Eosinophilic pustular folliculitis (Ofuji's disease): indomethacin as a first choice of treatment.
MedLine Citation:
PMID:  11298111     Owner:  NLM     Status:  MEDLINE    
Eosinophilic pustular folliculitis (EPF) is characterized by erythematous patches of large follicular papules and pustules involving mainly the face. Although various treatments have been attempted for EPF, including systemic and topical steroid, diaphenylsulphone, colchicine, minocycline as well as UVB phototherapy, there is no consensus on the first choice of treatment. We report a typical case and summarize 25 patients with EPF treated in our hospital between 1978 and 1998. Indomethacin was most frequently used (12/25) and showed clinical improvement in the majority of the cases (11/12). The effect of indomethacin was usually observed within 1--2 weeks after initiation of treatment. Decrease of peripheral blood eosinophils accompanied the clinical improvement. Thus, indomethacin should be considered as a first choice of treatment for EPF.
T Ota; Y Hata; A Tanikawa; M Amagai; M Tanaka; T Nishikawa
Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Clinical and experimental dermatology     Volume:  26     ISSN:  0307-6938     ISO Abbreviation:  Clin. Exp. Dermatol.     Publication Date:  2001 Mar 
Date Detail:
Created Date:  2001-04-12     Completed Date:  2001-05-31     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  7606847     Medline TA:  Clin Exp Dermatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  179-81     Citation Subset:  IM    
Department of Dermatology, Keio University School of Medicine, Tokyo, Japan.
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MeSH Terms
Anti-Inflammatory Agents, Non-Steroidal / therapeutic use*
Combined Modality Therapy
Eosinophilia / drug therapy*,  radiotherapy
Folliculitis / drug therapy*,  radiotherapy
Indomethacin / therapeutic use*
Middle Aged
Ultraviolet Therapy
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 53-86-1/Indomethacin

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