| Eosinophilic myeloid neoplasms. | |
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MedLine Citation:
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PMID: 23385615 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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PURPOSE OF REVIEW: In 2012, idiopathic hypereosinophilic syndrome (HES) is still the prevalent diagnosis in patients with persistent eosinophilia, in which a primary or secondary cause of eosinophilia has not been identified. HES is considered a provisional diagnosis until a primary or secondary cause of hypereosinophilia is established. The discovery of imatinib-sensitive fusion proteins in a subset of patients with hypereosinophilia has changed the way we approach the diagnosis and treatment of eosinophilic myeloid neoplasms [eosinophilic myeloproliferative neoplasms (MPNs)]. Despite the recent diagnostic developments, diagnosis of hypereosinophilic MPN is only made in 10-20% of patients with persistent primary hypereosinophilia. RECENT FINDINGS: In 2008 the World Health Organization (WHO) established a semi-molecular classification of hypereosinophilic MPNs. The discovery of PDGFRA, PDGFRB, FGFR1, JAK-2, and FLT3 fusion proteins in patients with eosinophilic MPNs provide opportunities for targeted therapy. Patients with hypereosinophilic MPNs associated with PDGFRA and PDGFRB fusion genes are responsive to imatinib. SUMMARY: Ongoing research continues to expand our understanding of the pathophysiology of persistent primary hypereosinophilia and clarify the boundaries between some of these disorders. A key challenge is to identify new targets for therapy and limit the number of patients who are classified as having HES. |
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Authors:
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Pierre Noel; Ruben A Mesa |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Current opinion in hematology Volume: 20 ISSN: 1531-7048 ISO Abbreviation: Curr. Opin. Hematol. Publication Date: 2013 Mar |
Date Detail:
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Created Date: 2013-02-06 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9430802 Medline TA: Curr Opin Hematol Country: United States |
Other Details:
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Languages: eng Pagination: 157-62 Citation Subset: IM |
Affiliation:
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Division of Hematology Oncology, Mayo Clinic Arizona, Scottsdale, Arizona, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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