Document Detail


Eosinophilic leukemic transformation in polycythemia rubra vera (PRV).
MedLine Citation:
PMID:  15621837     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We report a rare case of eosinophilic leukemia transformation in a patient with polycythemia rubra vera on hydroxycarbamide (hydroxyurea) therapy only. Cytogenetic study showed complex abnormalities including -5, -7, +8, suggestive of a secondary leukemia. The leukemogenic risk of hydroxycarbamide, a ribonucleoside reductase, and the risk of natural leukemic transformation of polycythemia rubra vera is discussed in the context of previous PVSG studies.
Authors:
C S Chim; S K Ma
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Leukemia & lymphoma     Volume:  46     ISSN:  1042-8194     ISO Abbreviation:  Leuk. Lymphoma     Publication Date:  2005 Mar 
Date Detail:
Created Date:  2004-12-28     Completed Date:  2005-06-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9007422     Medline TA:  Leuk Lymphoma     Country:  England    
Other Details:
Languages:  eng     Pagination:  447-50     Citation Subset:  IM    
Affiliation:
University Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong. jcschim@hkucc.hku.hk
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MeSH Terms
Descriptor/Qualifier:
Aged
Chromosome Aberrations
Cytogenetic Analysis
Humans
Hydroxyurea / therapeutic use
Hypereosinophilic Syndrome / complications*,  drug therapy,  pathology
Male
Polycythemia Vera / complications*,  drug therapy
Chemical
Reg. No./Substance:
127-07-1/Hydroxyurea

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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