| Eosinophilic leukemic transformation in polycythemia rubra vera (PRV). | |
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MedLine Citation:
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PMID: 15621837 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We report a rare case of eosinophilic leukemia transformation in a patient with polycythemia rubra vera on hydroxycarbamide (hydroxyurea) therapy only. Cytogenetic study showed complex abnormalities including -5, -7, +8, suggestive of a secondary leukemia. The leukemogenic risk of hydroxycarbamide, a ribonucleoside reductase, and the risk of natural leukemic transformation of polycythemia rubra vera is discussed in the context of previous PVSG studies. |
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Authors:
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C S Chim; S K Ma |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Leukemia & lymphoma Volume: 46 ISSN: 1042-8194 ISO Abbreviation: Leuk. Lymphoma Publication Date: 2005 Mar |
Date Detail:
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Created Date: 2004-12-28 Completed Date: 2005-06-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9007422 Medline TA: Leuk Lymphoma Country: England |
Other Details:
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Languages: eng Pagination: 447-50 Citation Subset: IM |
Affiliation:
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University Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong. jcschim@hkucc.hku.hk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Chromosome Aberrations Cytogenetic Analysis Humans Hydroxyurea / therapeutic use Hypereosinophilic Syndrome / complications*, drug therapy, pathology Male Polycythemia Vera / complications*, drug therapy |
| Chemical | |
Reg. No./Substance:
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127-07-1/Hydroxyurea |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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