Document Detail

Eosinophilic infiltration with flame figures. A distinctive tissue reaction seen in Wells' syndrome and other diseases.
MedLine Citation:
PMID:  3728877     Owner:  NLM     Status:  MEDLINE    
We report five cases, all male, of diverse clinical findings of scattered erythematous, violaceous, or centrally blue plaques. Eight biopsies from the five patients showed nodular or diffuse dermal and subcutaneous infiltration, predominantly of eosinophils and histiocytes, with "flame figures" composed of granules of eosinophils that surround collagen bundles, whose staining quality is thereby altered. Two patients were children, the younger only 18 months old. Three patients initially presented clinical evidence of insect bites, and in one of these the biopsy showed cutaneous pseudolymphoma underlying dermal changes of eosinophilic cellulitis. Eosinophilic infiltration with flame figures is a distinctive reaction to various stimuli. It may be seen in a wide variety of clinical conditions and is not confined solely to patients with Wells' syndrome, which may be an acceptable term for clinically typical cases. Eosinophilic infiltration with flame figures is preferred descriptively to identify the microscopic changes in Wells' syndrome and in other cases like that of our patient with pseudolymphoma, in which the cutaneous reaction may be secondary to some other disease.
C Wood; A C Miller; A Jacobs; R Hart; B J Nickoloff
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The American Journal of dermatopathology     Volume:  8     ISSN:  0193-1091     ISO Abbreviation:  Am J Dermatopathol     Publication Date:  1986 Jun 
Date Detail:
Created Date:  1986-07-28     Completed Date:  1986-07-28     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7911005     Medline TA:  Am J Dermatopathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  186-93     Citation Subset:  IM    
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MeSH Terms
Cellulitis / etiology,  pathology*,  physiopathology
Diagnosis, Differential
Eosinophilia / etiology,  pathology*,  physiopathology
Insect Bites and Stings / complications
Lymphoma / pathology
Middle Aged
Skin / pathology
Skin Neoplasms / pathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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