Document Detail

Eosinophilic gastroenteritis.
MedLine Citation:
PMID:  12228038     Owner:  NLM     Status:  MEDLINE    
Eosinophilic gastroenteritis is a rare gastrointestinal (GI) disorder of undetermined cause characterized by infiltration of eosinophils in the GI tract. Eosinophils accumulate in tissues and may release highly cytotoxic granular proteins, which cause severe tissue damage characteristic of eosinophilic gastroenteritis. Eotaxin may play a role in the recruitment of eosinophils into tissue in combination with chemoattractants and cytokines, including interleukin 3 and 5 and granulocyte-macrophage colony-stimulating factor. Food allergy, especially in children, can be a triggering factor, and an amino acid-based diet may be helpful. Accumulation of eosinophils in the gut is a common feature in food-induced GI disorders that can be regulated through a complex molecular network involving Th2 cells, various cytokines, and chemokines. Eosinophilic gastroenteritis has a wide spectrum of clinical presentation depending on the site of involvement. It may be confused with irritable bowel syndrome or dyspepsia and, rarely, mimics pancreatitis or appendicitis. Diagnosis is important and is usually made by a pathologist. Eosinophilic gastroenteritis is a treatable disease; patients generally respond to steroid therapy, although relapse is common. Non-enteric-coated budesonide, a locally acting corticosteroid with little risk of adrenal suppression, may be substituted, although more experience is needed. Promising new drugs for eosinophilic gastroenteritis include montelukast, a selective leukotriene receptor antagonist, and suplaplast tosilate, a selective Th2 cytokine inhibitor with inhibitory effects on allergy-induced eosinophilic infiltration and IgE production. Although it is likely a separate disease, more experience has accumulated, and an elimination or specific amino acid-based diet appears to be helpful in treatment.
Rahim Daneshjoo; Nicholas J Talley
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current gastroenterology reports     Volume:  4     ISSN:  1522-8037     ISO Abbreviation:  Curr Gastroenterol Rep     Publication Date:  2002 Oct 
Date Detail:
Created Date:  2002-09-13     Completed Date:  2002-11-29     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  100888896     Medline TA:  Curr Gastroenterol Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  366-72     Citation Subset:  IM    
University of Sydney, Nepean Hospital, Level 5 South Block, PO Box 63, Penrith NSW 2751, Australia.
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MeSH Terms
Chemotactic Factors, Eosinophil / metabolism
Child, Preschool
Clinical Trials as Topic
Cytokines / metabolism
Eosinophilia / etiology*,  physiopathology*,  therapy
Food Hypersensitivity / complications,  diagnosis
Gastroenteritis / etiology*,  physiopathology*,  therapy
Parasitic Diseases / complications,  diagnosis
Pharmaceutical Preparations / adverse effects
Risk Factors
Severity of Illness Index
Reg. No./Substance:
0/Chemotactic Factors, Eosinophil; 0/Cytokines; 0/Pharmaceutical Preparations

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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