Document Detail


Eosinophilic esophagitis in cystic fibrosis: a case series and review of the literature.
MedLine Citation:
PMID:  23085252     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Patients with cystic fibrosis (CF) frequently experience gastrointestinal symptoms including nausea, emesis, malnutrition and indigestion; diseases such as gastroesophageal reflux disease (GERD), distal intestinal obstructive syndrome, and cholelithiasis are commonly implicated. We have recently diagnosed eosinophilic esophagitis (EoE) in three patients with CF. EoE is a TH-2 driven, allergen-mediated disease which causes esophageal eosinophilia and presents with symptoms of nausea, feeding intolerance, regurgitation, and dysphagia. EoE is diagnosed when esophageal biopsies reveal greater than 15 eosinophils per high power field in the setting of the appropriate clinical scenario and after exclusion of other causes of esophageal eosinophilia. Although described with increasing frequently in the gastrointestinal literature, there have been no prior cases documenting the co-existence of EoE and CF. We speculate that this is related to lack of familiarity with EoE symptoms by CF providers. We present three patients with CF diagnosed with EoE and review the current literature regarding diagnosis and management, focusing on management issues in patients with CF.
Authors:
Jennifer L Goralski; Daniel M Lercher; Stephanie D Davis; Evan S Dellon
Publication Detail:
Type:  Case Reports; Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2012-10-22
Journal Detail:
Title:  Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society     Volume:  12     ISSN:  1873-5010     ISO Abbreviation:  J. Cyst. Fibros.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-11     Completed Date:  2013-05-23     Revised Date:  2014-01-09    
Medline Journal Info:
Nlm Unique ID:  101128966     Medline TA:  J Cyst Fibros     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  9-14     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Budesonide / administration & dosage
Child, Preschool
Cystic Fibrosis / complications*,  immunology
Eosinophilic Esophagitis / complications*,  diagnosis,  drug therapy
Female
Glucocorticoids / administration & dosage
Humans
Prognosis
Grant Support
ID/Acronym/Agency:
1K23 DK090073-01/DK/NIDDK NIH HHS; K23 DK090073/DK/NIDDK NIH HHS; T32 HL007106/HL/NHLBI NIH HHS; T32 HL007106-35/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Glucocorticoids; 51333-22-3/Budesonide
Comments/Corrections

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