| Eosinophilic esophagitis in adults: clinical, endoscopic, histologic findings, and response to treatment with fluticasone propionate. | |
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MedLine Citation:
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PMID: 16377308 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Eosinophilic esophagitis is an increasingly recognized disorder characterized by intense eosinophilic infiltration of the esophageal mucosa. The aim of this study was to define the clinical syndrome, the endoscopic features, and the distribution of the eosinophil infiltrate in adults with eosinophilic esophagitis. We undertook a prospective evaluation of the symptomatic and histologic response to treatment with fluticasone propionate. METHODS: Twenty-six patients (18 men; mean age 36 years) had symptom assessment and barium studies, esophageal motility recordings, and 24-hour esophageal pH studies. Upper-GI endoscopy was performed with quantitative eosinophil counts of biopsy specimens from the proximal and distal esophagus, the gastric antrum, and the duodenum. Nineteen subjects received 4 weeks of swallowed fluticasone propionate. After treatment, symptom assessment and endoscopic biopsies were repeated. RESULTS: All 26 patients had a history of dysphagia, and 11 presented acutely with food-bolus obstruction. Esophageal peristalsis was normal in most and gastroesophageal reflux coexisted in 10 patients. Characteristic endoscopic findings of furrows (20) and rings (18) were observed. All 19 treated patients had symptom improvement and a significant decrease in esophageal eosinophil counts. CONCLUSIONS: Eosinophilic esophagitis is a distinct entity that may coexist with gastroesophageal reflux. Swallowed fluticasone propionate is an effective treatment. |
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Authors:
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Matthew Remedios; Catherine Campbell; Dianne M Jones; Paul Kerlin |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Gastrointestinal endoscopy Volume: 63 ISSN: 0016-5107 ISO Abbreviation: Gastrointest. Endosc. Publication Date: 2006 Jan |
Date Detail:
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Created Date: 2005-12-26 Completed Date: 2006-04-25 Revised Date: 2007-10-04 |
Medline Journal Info:
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Nlm Unique ID: 0010505 Medline TA: Gastrointest Endosc Country: United States |
Other Details:
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Languages: eng Pagination: 3-12 Citation Subset: IM |
Affiliation:
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Department of Gastroenterology and Hepatology, Princess Alexandra Hospital, Brisbane, Queensland, Australia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenal Cortex Hormones
/
administration & dosage,
therapeutic use* Adult Androstadienes / administration & dosage, therapeutic use* Deglutition Disorders / etiology Duodenum / pathology Endoscopy, Gastrointestinal Eosinophils / pathology Esophagitis / drug therapy*, pathology*, physiopathology Esophagus / pathology Gastroesophageal Reflux / complications Humans Leukocyte Count Male Mucous Membrane / pathology Prospective Studies Pyloric Antrum / pathology |
| Chemical | |
Reg. No./Substance:
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0/Adrenal Cortex Hormones; 0/Androstadienes; 90566-53-3/fluticasone |
| Comments/Corrections | |
Comment In:
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Gastrointest Endosc. 2006 Jan;63(1):13-5
[PMID:
16377309
]
Rev Gastroenterol Disord. 2006 Fall;6(4):245-7 [PMID: 17224897 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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