Document Detail

Eosinophilic colitis: an update on pathophysiology and treatment.
MedLine Citation:
PMID:  22012125     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Primary eosinophilic gastrointestinal disorders, a spectrum of inflammatory conditions, occurs when eosinophils selectively infiltrate the gut in the absence of known causes for such tissue eosinophilia. These may be classified into eosinophilic esophagitis, eosinophilic gastroenteritis and eosinophilic colitis (EC). This review focuses on EC: its pathogenesis, epidemiology, clinical presentation, diagnosis and current approach to treatment.
SOURCES OF DATA: A literature review published in English was performed using Pubmed, Ovid, Google scholar search engines with the following keywords: eosinophilic gastrointestinal disorder, EC, eosinophils, colitis and gastrointestinal.
AREAS OF AGREEMENT: The basis for primary EC appears related to increased sensitivity to allergens, principally as a food allergy in infants and a T lymphocyte-mediated event in adults. Endoscopic changes are generally modest, featuring edema and patchy granularity.
AREAS OF CONTROVERSY: Clear clinical and pathological diagnostic criteria of EC and its management strategy.
GROWING POINTS: Intestinal involvement of EC is primarily mucosal, presenting as a mild self-limited proctitis in infants and self-limited colitis in young adults. Therapeutic approaches based on case reports tend to use either elimination diets to avoid a presumed allergen; agents traditionally used in inflammatory disease or targeted drugs like anti-histamines or leukotriene receptor antagonists.
AREAS TIMELY FOR DEVELOPING RESEARCH: Prospective randomized controlled trials addressing the disease natural history, possible preventive methods and effective medical approach and long-term prognosis are required.
Abdulrahman A Alfadda; Martin A Storr; Eldon A Shaffer
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Publication Detail:
Type:  Journal Article; Review     Date:  2011-10-19
Journal Detail:
Title:  British medical bulletin     Volume:  100     ISSN:  1471-8391     ISO Abbreviation:  Br. Med. Bull.     Publication Date:  2011  
Date Detail:
Created Date:  2011-12-13     Completed Date:  2012-03-15     Revised Date:  2012-09-10    
Medline Journal Info:
Nlm Unique ID:  0376542     Medline TA:  Br Med Bull     Country:  England    
Other Details:
Languages:  eng     Pagination:  59-72     Citation Subset:  IM    
Division of Gastroenterology, Faculty of Medicine, University of Calgary, Teaching Research & Wellness Building, Room 6D48, 3280 Hospital Dr NW, Calgary, AB, Canada T2N4N1.
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MeSH Terms
Colitis / diagnosis,  epidemiology,  etiology,  therapy*
Diagnosis, Differential
Eosinophilia / diagnosis,  epidemiology,  etiology,  therapy*
Food Hypersensitivity / complications

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