Document Detail


Eosinophilic cationic protein in chronic eosinophilic pneumonia and eosinophilic granuloma.
MedLine Citation:
PMID:  7956407     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We measured eosinophilic cationic protein (ECP) concentrations in the circulation and bronchoalveolar lavage (BAL) fluids from patients with chronic eosinophilic pneumonia, patients with eosinophilic granuloma, and normal control subjects. Significantly increased ECP concentrations were found in the circulation of patients with chronic eosinophilic pneumonia and with eosinophilic granuloma compared with those found in control subjects. The ECP concentrations were well correlated to eosinophil counts in the circulation of patients with chronic eosinophilic pneumonia, while they were not in patients with eosinophilic granuloma. Chronic eosinophilic pneumonia patients had prominently increased ECP concentrations in BAL fluids compared with those found in control subjects, while eosinophilic granuloma patients did not. Those concentrations in chronic eosinophilic pneumonia patients were well correlated to eosinophil counts in the BAL fluid. Corticosteroid therapy remarkably decreased circulating ECP concentrations in three patients with chronic eosinophilic pneumonia, but it had no significant effects in two patients with eosinophilic granuloma. Measurement of ECP concentrations seems to be useful to evaluate the disease activity of chronic eosinophilic pneumonia.
Authors:
N Shijubo; K Shigehara; M Hirasawa; M Inuzuka; S Abe
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Chest     Volume:  106     ISSN:  0012-3692     ISO Abbreviation:  Chest     Publication Date:  1994 Nov 
Date Detail:
Created Date:  1994-12-09     Completed Date:  1994-12-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1481-6     Citation Subset:  AIM; IM    
Affiliation:
Third Department of Internal Medicine, Sapporo Medical University School of Medicine, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Blood Proteins / analysis*
Bronchoalveolar Lavage Fluid / chemistry
Chronic Disease
Eosinophil Granule Proteins
Eosinophilic Granuloma / metabolism*
Eosinophils / cytology
Humans
Least-Squares Analysis
Leukocyte Count
Middle Aged
Pulmonary Eosinophilia / metabolism*
Radioimmunoassay
Ribonucleases*
Smoking / metabolism
Statistics, Nonparametric
Chemical
Reg. No./Substance:
0/Blood Proteins; 0/Eosinophil Granule Proteins; EC 3.1.-/Ribonucleases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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