Document Detail

Eosinophilic angiocentric fibrosis and granuloma faciale: analysis of cellular infiltrate and review of literature.
MedLine Citation:
PMID:  15697160     Owner:  NLM     Status:  MEDLINE    
Eosinophilic angiocentric fibrosis (EAF) is a rare specific inflammatory condition that affects the nose and upper airways and is characterized by distinctive histopathologic features. We report the clinical, histopathologic, and radiologic features of EAF in an elderly woman who presented to us with complete stenosis of the left nostril, nasal swelling, and granuloma faciale (GF) of the overlying nasal skin. The histopathologic spectrum of the early, intermediate, and late stages of EAF in the deeper nasal tissues is illustrated along with the adjacent changes of GF in the overlying nasal skin. Quantification of immunohistochemically stained lymphocyte cell subsets in the perivascular inflammatory component was performed by using software to compare the proportions of lymphocyte subsets in the two conditions. The results showed similar proportions of perivascular CD4 T lymphocytes in EAF and GF. We believe that both EAF and GF may represent unusual tissue responses. Similar analysis in other cases will help confirm these findings. A review of the literature suggests that the condition, if localized, is amenable to surgical treatment. In progressive late stages, EAF causes fibrotic stenosis of the affected site with localized extension.
Jeena Narayan; Anthony G Douglas-Jones
Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  The Annals of otology, rhinology, and laryngology     Volume:  114     ISSN:  0003-4894     ISO Abbreviation:  Ann. Otol. Rhinol. Laryngol.     Publication Date:  2005 Jan 
Date Detail:
Created Date:  2005-02-08     Completed Date:  2005-02-25     Revised Date:  2006-05-15    
Medline Journal Info:
Nlm Unique ID:  0407300     Medline TA:  Ann Otol Rhinol Laryngol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  35-42     Citation Subset:  AIM; IM    
Department of ENT, University Hospital of Wales, Cardiff, Wales.
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MeSH Terms
Eosinophilia / diagnosis*
Facial Dermatoses / diagnosis*
Granuloma / diagnosis*
Nasal Cavity*
Nasal Obstruction / etiology*

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