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Eosinophilic airway inflammation is increased in children with asthma and food allergies.
MedLine Citation:
PMID:  22104024     Owner:  NLM     Status:  Publisher    
To cite this article: Kulkarni N, Ragazzo V, Costella S, Piacentini G, Boner A, O'Callaghan C, Fiocchi A, Kantar A. Eosinophilic airway inflammation is increased in children with asthma and food allergies. Pediatr Allergy Immunol 2011; Doi: 10.1111/j.1399-3038.2011.01226.x ABSTRACT: Background:  Asthma is associated with food allergies in a significant number of children, with evidence linking allergies to asthma severity and morbidity. In this study, we tested our hypothesis that the eosinophilic lower airway inflammation is higher in asthmatic children with food allergies. Aims:  The aims of the study were to compare the eosinophilic inflammatory markers in asthmatic children with and without food allergies. Materials and Methods:  Children with asthma, with (n = 22) and (n = 53) without food allergies were included. All subjects were classified according to the GINA guidelines (2009) and had received at least 3 months of anti-inflammatory therapy prior to testing. Fractional exhaled nitric oxide and sputum differential counts were performed using standard techniques. Results:  Children with asthma and food allergies had significantly higher fractional exhaled nitric oxide median (range) [(22.4 (6.1-86.9) vs. 10.3 (2.7-38.7) (p = 0.01)] and sputum eosinophil percentage [15.5 (5.0-53.0) vs. 2.0 (0-20) (p < 0.001)] compared with asthmatic children without allergies. Conclusion:  These results suggest that the children with asthma and food allergies have increased eosinophilic inflammation of the airways.
Neeta Kulkarni; Vincenzo Ragazzo; Silvia Costella; Giorgio Piacentini; Attilio Boner; Christopher O'Callaghan; Alessandro Fiocchi; Ahmad Kantar
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-11-22
Journal Detail:
Title:  Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology     Volume:  -     ISSN:  1399-3038     ISO Abbreviation:  -     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-11-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9106718     Medline TA:  Pediatr Allergy Immunol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2011 John Wiley & Sons A/S.
High Altitude Paediatric Asthma Centre in Misurina, Pio XII Institute, Misurina, Belluno, Italy Department of Infection, Immunity and Inflammation & Institute for Lung Health, University of Leicester, Leicester, UK Department of Pediatrics, University of Verona, Italy Department of Child and Maternal Medicine, Melloni University Hospital, Milan, Italy.
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