| Eosinophilic inflammation in allergic rhinitis and nasal polyposis. | |
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MedLine Citation:
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PMID: 22202468 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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On histopathological examination, nasal polyps and nasal mucosa in allergic rhinitis show different forms of pseudostratified respiratory epithelium, whereas the dominant characteristic of lamina propria is an eosinophilic infiltration. The aim of this study was to compare interleukin (IL)-5 and eosinophilic cationic protein (ECP) levels in the nasal fluid of 42 patients: 12 with allergic rhinitis and nasal septal deviation, 17 non-atopic patients with nasal polyposis, and 13 atopic nasal polyp patients were enrolled in this cross-sectional study. Nasal secretion samples were collected a few days before surgery. The levels of IL-5 were measured using flow cytometry and the ECP using a commercial ELISA kit. In addition, we counted eosinophils in hematoxylin-and-eosin-stained sections of all nasal polyp and all nasal mucosa samples taken from the inferior nasal turbinates during septoplasty. A significantly higher concentration of IL-5 was found in the nasal fluid of atopic patients with nasal polyposis than in non-atopic nasal polyp patients (p=0.025) and patients with allergic rhinitis (p=0.05). ECP was higher in atopic nasal polyp patients than in patients with allergic rhinitis (p<0.0001) and than in non-atopic nasal polyp patients (p<0.0001). Polyp eosinophils were higher in atopic' than in non-atopic patients (p<0.0001) and higher than in the mucosa of patients with allergic rhinitis (p<0.0001). These however had significantly more mucosal eosinophils than was found in the polyps of non-atopic patients' (p=0.025). ECP levels in nasal fluid and eosinophil counts in tissue specimens correlated well in all three groups of patients. Our study has shown that atopic nasal polyp patients have a higher level of eosinophilic inflammation than non-atopic patients with nasal polyps and patients with allergic rhinitis. |
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Authors:
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Aleksandar Perić; Danilo Vojvodić; Biserka Vukomanović-Đurđević; Nenad Baletić |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Arhiv za higijenu rada i toksikologiju Volume: 62 ISSN: 0004-1254 ISO Abbreviation: Arh Hig Rada Toksikol Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-28 Completed Date: 2012-04-26 Revised Date: 2012-05-03 |
Medline Journal Info:
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Nlm Unique ID: 0373100 Medline TA: Arh Hig Rada Toksikol Country: Croatia |
Other Details:
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Languages: eng Pagination: 341-8 Citation Subset: IM |
Affiliation:
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Department of Otorhinolaryngology, Military Medical Academy, Belgrade, Serbia. alexneta@sezampro.rs |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Eosinophil Cationic Protein / metabolism Eosinophils / pathology* Female Humans Immunoglobulin E / blood Inflammation Interleukin-5 / metabolism Male Middle Aged Nasal Mucosa / metabolism, pathology* Nasal Polyps / metabolism, pathology* Rhinitis, Allergic, Perennial / metabolism, pathology* Rhinitis, Allergic, Seasonal / metabolism, pathology* |
| Chemical | |
Reg. No./Substance:
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0/Interleukin-5; 37341-29-0/Immunoglobulin E; EC 3.1.27.-/Eosinophil Cationic Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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