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Eosinophilic-Crohn overlap colitis and review of the literature.
MedLine Citation:
PMID:  21575892     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Eosinophilic colitis is an idiopathic inflammation of the alimentary canal and is characterized by infiltration of the intestinal wall by eosinophils, massive submucosal edema, and peripheral eosinophilia. However, the presence of eosinophils in a colon biopsy requires thorough searching for secondary causes and eosinophilic colitis remains a diagnosis of exclusion. A 67-year-old male patient underwent a diagnostic ileocolonoscopy because of recurrent episodes of diarrhea for the last six months. Colonoscopy revealed a normal terminal ileum while in the entire colon an erythematous mucosa with very slight edema on a continuous pattern that was more pronounced in the left colon. The laboratory workup demonstrated eosinophils slightly elevated, biochemical tests were unremarkable and further clinical and laboratory workup was unremarkable. Histology showed overlapping findings of eosinophilic colitis and Crohn's colitis. Patient started on mesalazine 2.4 with very good results. A review of the literature shows that the spectrum of eosinophil involvement in inflammatory bowel disease as well as in eosinophilic colitis is largely varying, including also some exceptional cases that parallel the case described herein.
Authors:
Konstantinos H Katsanos; Eirini Zinovieva; Evangelia Lambri; Epameinondas V Tsianos
Publication Detail:
Type:  Journal Article     Date:  2011-03-10
Journal Detail:
Title:  Journal of Crohn's & colitis     Volume:  5     ISSN:  1876-4479     ISO Abbreviation:  J Crohns Colitis     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-05-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101318676     Medline TA:  J Crohns Colitis     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  256-61     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 European Crohn's and Colitis Organisation. Published by Elsevier B.V. All rights reserved.
Affiliation:
1st Division of Internal Medicine and Hepato-gastroenterology Unit, Medical School, University of Ioannina, GR 45110, Greece.
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