Document Detail


Eosinophilia and progression to active tuberculosis in HIV-1-infected Ugandans.
MedLine Citation:
PMID:  15259486     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
It has been suggested that type 1 immune responses protect against tuberculosis (TB), while type 2 responses, such as those induced by helminths, may suppress protective responses and increase susceptibility to TB. Factors associated with progression to active TB were investigated in a cohort of HIV-1-infected Ugandan adults, a group at high risk of TB. High rates of subsequent progression to active TB were associated with eosinophil counts > or = 0.4 x 10(9)/L at enrolment. Eosinophilia at enrolment was associated with male gender, low socio-economic status, high CD4+ T cell counts, and schistosomiasis, but adjusting for these factors did not explain the association of eosinophilia with progression to active TB (adjusted rate ratio = 2.76, P = 0.004). Eosinophilia is most likely to be indicative of a type 2 immune response induced by helminth infection in this Ugandan cohort, but the mechanism of the observed association between eosinophilia and risk of TB remains to be determined.
Authors:
Alison M Elliott; Jacqueline Kyosiimire; Maria A Quigley; Jessica Nakiyingi; Christine Watera; Michael Brown; Sarah Joseph; Neil French; Charles F Gilks; James A G Whitworth
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Transactions of the Royal Society of Tropical Medicine and Hygiene     Volume:  97     ISSN:  0035-9203     ISO Abbreviation:  Trans. R. Soc. Trop. Med. Hyg.     Publication Date:    2003 Jul-Aug
Date Detail:
Created Date:  2004-07-19     Completed Date:  2004-10-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7506129     Medline TA:  Trans R Soc Trop Med Hyg     Country:  England    
Other Details:
Languages:  eng     Pagination:  477-80     Citation Subset:  IM    
Affiliation:
Virus Research Institute, PO Box 49, Entebbe, Uganda. mrc@starcom.co.ug
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MeSH Terms
Descriptor/Qualifier:
AIDS-Related Opportunistic Infections / complications*
Adult
Disease Progression
Eosinophilia / complications*
Female
Follow-Up Studies
HIV Infections / complications*
HIV-1*
Humans
Male
Risk Factors
Schistosomiasis / complications
Social Class
Tuberculosis / complications*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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