Document Detail

Eosinophilia myalgia syndrome.
MedLine Citation:
PMID:  9213377     Owner:  NLM     Status:  MEDLINE    
The term eosinophilia myalgia syndrome (EMS) was coined in 1989 after a cluster of cases with symptoms of incapacitating myalgias and eosinophilia were reported. This syndrome has been only defined as varying degrees of myalgias and peripheral eosinophilia. Case reports of EMS are protean and do not show a consistent clinical picture, raising the question of whether this reflects a single disorder or is a conflation of various disorders. There have been only two studies evaluating the association of EMS with 1-tryptophan. These two included only 23 patients with EMS. Apart from the obvious statistical fragility inherent in such small studies, each is further weakened by differences in the mechanisms by which patients and controls were selected. Furthermore, the continued reports of EMS after 1-tryptophan was removed from the market raise additional questions about the association. Nonetheless, there has been an inordinate reliance on a history of 1-tryptophan ingestion in making the diagnosis of EMS. When presented case studies, clinicians were much more likely to make the diagnosis of EMS when a history of 1-tryptophan ingestion was included. These observations underscore the need for careful application of well-considered diagnostic criteria to the study of new syndromes and their potential associations.
W D Blackburn
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Seminars in arthritis and rheumatism     Volume:  26     ISSN:  0049-0172     ISO Abbreviation:  Semin. Arthritis Rheum.     Publication Date:  1997 Jun 
Date Detail:
Created Date:  1997-08-21     Completed Date:  1997-08-21     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  1306053     Medline TA:  Semin Arthritis Rheum     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  788-93     Citation Subset:  IM    
Division of Clinical Immunology and Rheumatology, Birmingham VA Hospital (111-F), AL 35233, USA.
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MeSH Terms
Diagnosis, Differential
Eosinophilia-Myalgia Syndrome / chemically induced,  diagnosis*
Tryptophan / adverse effects
Reg. No./Substance:
Comment In:
Semin Arthritis Rheum. 1997 Jun;26(6):781-4   [PMID:  9213375 ]

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