| Eosinophilia-myalgia syndrome in patients ingesting a single source of L-tryptophan. | |
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MedLine Citation:
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PMID: 8474064 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To estimate the attack rate for eosinophilia-myalgia syndrome and to identify potential risk factors for illness among patients attending a New York City medical clinic, who purchased L-tryptophan containing products produced exclusively by Showa Denko K.K. METHODS: A case-control design was used. Cases and controls purchased L-tryptophan containing products at the medical clinic from July 1, 1989--December 1, 1989. All case-patients identified with illness onset during the study period were included. Controls were selected by a systematic sample of the 683 purchasers of L-tryptophan attending the same clinic. RESULTS: Twelve (2.2%) of an estimated 553 L-tryptophan users were case-patients. Multivariate analysis suggested that lot 2 use (adjusted odds ratio [OR] = 35.9), concomitant use of chromium (adjusted OR = 12.3), and concomitant use of pyridoxine (adjusted OR = 5.8) were associated with the development of illness. Chemical analysis of tablets corresponding to the 3 Showa Denko K.K. lots ingested by study participants showed that lot 2 had the highest concentration of ethylidenebis (L-tryptophan), a proposed causative agent or marker for a causative agent in the eosinophilia-myalgia syndrome. CONCLUSIONS: Information from our study of persons exposed to implicated L-tryptophan supports the role for a contaminant as the causative agent in the eosinophilia-myalgia syndrome and identifies possible cofactors that deserve further study. |
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Authors:
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K J Henning; E Jean-Baptiste; T Singh; R H Hill; S M Friedman |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of rheumatology Volume: 20 ISSN: 0315-162X ISO Abbreviation: J. Rheumatol. Publication Date: 1993 Feb |
Date Detail:
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Created Date: 1993-05-18 Completed Date: 1993-05-18 Revised Date: 2010-03-24 |
Medline Journal Info:
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Nlm Unique ID: 7501984 Medline TA: J Rheumatol Country: CANADA |
Other Details:
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Languages: eng Pagination: 273-8 Citation Subset: IM |
Affiliation:
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Division of Field Epidemiology, Centers for Disease Control, Atlanta, GA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Case-Control Studies Chromium / adverse effects Dose-Response Relationship, Drug Drug Interactions Eosinophilia-Myalgia Syndrome / chemically induced*, epidemiology Female Humans Male Middle Aged Multivariate Analysis New York City / epidemiology Pyridoxine / adverse effects Risk Factors Tryptophan / adverse effects* |
| Chemical | |
Reg. No./Substance:
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65-23-6/Pyridoxine; 73-22-3/Tryptophan; 7440-47-3/Chromium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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