Document Detail

Eosinophilia and granulocytic dysplasia terminating in acute myeloid leukaemia after 24 years.
MedLine Citation:
PMID:  8943897     Owner:  NLM     Status:  MEDLINE    
Eosinophilia of variable duration, and subsequent progression to granulocytic sarcoma and acute myeloid leukaemia, has been infrequently reported in the literature. We report a patient with eosinophilia and normal cytogenetics who, after 24 years, showed transformation to a granulocytic sarcoma of the brain. Haematological counts were normal but the marrow revealed the cytogenetic abnormality trisomy 8 in 25% of mitoses. Subsequently an AML-M2 developed, showing a complex karyotype including the trisomy 8 in all metaphases. FISH analysis combined with cytological examination identified the trisomy 8 in blasts, eosinophils and dysplastic granulocytes only. Thus progressive leukaemic transformation selectively involved the myeloid compartment.
J K Doorduijn; K van Lom; B Löwenberg
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  British journal of haematology     Volume:  95     ISSN:  0007-1048     ISO Abbreviation:  Br. J. Haematol.     Publication Date:  1996 Dec 
Date Detail:
Created Date:  1997-01-17     Completed Date:  1997-01-17     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372544     Medline TA:  Br J Haematol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  531-4     Citation Subset:  IM    
Department of Haematology, University Hospital Rotterdam, The Netherlands.
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MeSH Terms
Brain Neoplasms / etiology
Cell Transformation, Neoplastic
Chromosomes, Human, Pair 8
Disease Progression
Eosinophilia / complications*
Leukemia, Myeloid, Acute / etiology*
Middle Aged

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