Document Detail

Eosinophilia at the time of respiratory syncytial virus bronchiolitis predicts childhood reactive airway disease.
MedLine Citation:
PMID:  10617708     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Bronchiolitis in infancy is viewed as a risk factor for childhood asthma, but factors predicting which infants will have persistent wheezing have not been identified. In addition, the nature of the association between the 2 conditions is uncertain. We wished to determine whether eosinophil counts at the time of acute bronchiolitis predicted the presence of wheezing in later childhood. METHODS: We retrospectively identified infants hospitalized with bronchiolitis, determined peripheral blood eosinophil counts at the time of bronchiolitis, and then contacted their families when they had reached 7 years of age. RESULTS: Eosinophil counts at the time of bronchiolitis were greater in subjects who would have wheezing at 7 years of age (median: 98 cells/mm(3)) than in infants who would have no recurrent wheezing (median: 0 cells/mm(3)) or transient wheezing only up to 3 years of age (median: 0 cells/mm(3)). When the effects of family history of asthma, gender, and passive exposure to cigarette smoke were examined, only eosinophilia at the time of bronchiolitis demonstrated a statistically significant relationship to the presence of wheezing at 7 years of age. CONCLUSIONS: Eosinophilia at the time of bronchiolitis generally predicts the development of wheezing persisting into later childhood. Therefore, the association of bronchiolitis and childhood asthma seems more likely to be attributable to an immunologic anomaly that precedes the development of, or is induced by, bronchiolitis rather than to structural damage to the airway as a result of bronchiolitis.
D R Ehlenfield; K Cameron; R C Welliver
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatrics     Volume:  105     ISSN:  0031-4005     ISO Abbreviation:  Pediatrics     Publication Date:  2000 Jan 
Date Detail:
Created Date:  2000-02-08     Completed Date:  2000-02-08     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  79-83     Citation Subset:  AIM; IM    
Department of Pediatrics, State University of New York at Buffalo, School of Medicine and Biomedical Sciences, and the Division of Infectious Diseases, Children's Hospital of Buffalo, Buffalo, New York.
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MeSH Terms
Bronchiolitis, Viral / epidemiology*
Child, Preschool
Leukocyte Count
Predictive Value of Tests
Pulmonary Eosinophilia / epidemiology*
Respiratory Sounds*
Respiratory Syncytial Virus Infections / epidemiology*
Retrospective Studies
Risk Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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