Document Detail

Eosinophil protein X and eosinophil cationic protein as indicators of intestinal inflammation in infants with atopic eczema and food allergy.
MedLine Citation:
PMID:  10520078     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The aim of this study was to evaluate the presence of allergic intestinal inflammation in infants with food allergy and atopic eczema before and after elimination diet, and to evaluate the use of eosinophil protein X (EPX) and eosinophil cationic protein (ECP) in the monitoring of inflammatory activity. METHODS: The study material comprised 25 infants with atopic dermatitis and food allergy. Thirteen healthy infants served as controls. Faecal and serum samples were collected before an elimination diet (on the first visit to the hospital) and approximately 3 months later for the determination of EPX and ECP. RESULTS: Before the elimination diet, infants with atopic dermatitis demonstrated markedly higher faecal concentrations of EPX and ECP than healthy controls (P = 0. 0003, P < 0.0001, respectively). The faecal concentrations of EPX and ECP showed a distinct decrease as a result of an adequate elimination diet in patients with favourable clinical response (P = 0.0027, P = 0.004, respectively). CONCLUSIONS: The results indicate the presence of marked intestinal inflammation in patients with atopic dermatitis and food allergy. The determination of faecal ECP and especially of faecal EPX provides a promising noninvasive tool in monitoring intestinal inflammation and disease activity in infants with atopic eczema and food allergy.
H Majamaa; S Laine; A Miettinen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology     Volume:  29     ISSN:  0954-7894     ISO Abbreviation:  Clin. Exp. Allergy     Publication Date:  1999 Nov 
Date Detail:
Created Date:  1999-12-10     Completed Date:  1999-12-10     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8906443     Medline TA:  Clin Exp Allergy     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1502-6     Citation Subset:  IM    
Medical School, University of Tampere, Finland.
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MeSH Terms
Biological Markers / analysis
Blood Proteins / analysis*
Dermatitis, Atopic / immunology*
Eosinophil Granule Proteins
Eosinophil-Derived Neurotoxin
Eosinophils* / immunology
Feces / chemistry
Food Hypersensitivity / immunology*,  prevention & control
Inflammation / immunology
Intestines / immunology*
Reg. No./Substance:
0/Biological Markers; 0/Blood Proteins; 0/Eosinophil Granule Proteins; EC 3.1.-/Eosinophil-Derived Neurotoxin; EC 3.1.-/Ribonucleases

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