Document Detail


Eosinophil-induced neurotoxicity: the role of eosinophil cationic protein/RNase 3.
MedLine Citation:
PMID:  20619905     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We analyze the effect of ECP on primary cultures of cerebellar granule cells (CGCs) and astrocytes in an effort to understand the role of ECP in the eosinophil-induced neurotoxicity. We have shown that ECP induces dose-dependent cell death in both CGCs and astrocytes. The effect of ECP action on cell morphology is consistent with apoptosis for both cell types. The apoptotic mechanism involves ECP binding on the cell surface and an increase in the free cytosolic Ca(2+) concentration. It is associated with the activation of caspase-3, -8 and -9, processes that are also involved in the apoptosis induced either by stroke or other neurodegenerative conditions. Our results open new insights to clarify the neurotoxic effects associated to ECP in the hypereosinophilic syndrome.
Authors:
Susanna Navarro; Ester Boix; Claudi M Cuchillo; M Victòria Nogués
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neuroimmunology     Volume:  227     ISSN:  1872-8421     ISO Abbreviation:  J. Neuroimmunol.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-20     Completed Date:  2010-10-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8109498     Medline TA:  J Neuroimmunol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  60-70     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier B.V. All rights reserved.
Affiliation:
Departament de Bioquímica i Biologia Molecular, Facultat de Biociències, Universitat Autònoma de Barcelona, 08193-Bellaterra, Spain.
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MeSH Terms
Descriptor/Qualifier:
Animals
Apoptosis Regulatory Proteins / physiology,  toxicity
Cell Death / immunology
Cells, Cultured
Cerebellum / enzymology,  immunology,  pathology
Dose-Response Relationship, Immunologic
Eosinophil Cationic Protein / physiology*,  toxicity
Eosinophils / enzymology*,  immunology,  pathology*
Humans
Neurotoxins / toxicity
Rats
Chemical
Reg. No./Substance:
0/Apoptosis Regulatory Proteins; 0/Neurotoxins; EC 3.1.27.-/Eosinophil Cationic Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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