| Eosinophil-induced neurotoxicity: the role of eosinophil cationic protein/RNase 3. | |
| | |
MedLine Citation:
|
PMID: 20619905 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We analyze the effect of ECP on primary cultures of cerebellar granule cells (CGCs) and astrocytes in an effort to understand the role of ECP in the eosinophil-induced neurotoxicity. We have shown that ECP induces dose-dependent cell death in both CGCs and astrocytes. The effect of ECP action on cell morphology is consistent with apoptosis for both cell types. The apoptotic mechanism involves ECP binding on the cell surface and an increase in the free cytosolic Ca(2+) concentration. It is associated with the activation of caspase-3, -8 and -9, processes that are also involved in the apoptosis induced either by stroke or other neurodegenerative conditions. Our results open new insights to clarify the neurotoxic effects associated to ECP in the hypereosinophilic syndrome. |
| | |
Authors:
|
Susanna Navarro; Ester Boix; Claudi M Cuchillo; M Victòria Nogués |
Related Documents
:
|
17216315 - Stimulation of the in vitro migration of ovine eosinophils by factors derived from the ... 12811015 - Nerve growth factor: neurotrophin or cytokine? 9698915 - Immune responses of il-5 transgenic mice to parasites and aeroallergens. 9027445 - Granulocyte function in the airways of allergen-challenged pigs: effects of inhaled and... 21686235 - The role of biliary epithelial cells in the immunopathogenesis of non-suppurative destr... 18803305 - Expression of syndecan-2 in the amoeboid microglial cells and its involvement in inflam... |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Journal of neuroimmunology Volume: 227 ISSN: 1872-8421 ISO Abbreviation: J. Neuroimmunol. Publication Date: 2010 Oct |
Date Detail:
|
Created Date: 2010-09-20 Completed Date: 2010-10-19 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8109498 Medline TA: J Neuroimmunol Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 60-70 Citation Subset: IM |
Copyright Information:
|
Copyright © 2010 Elsevier B.V. All rights reserved. |
Affiliation:
|
Departament de Bioquímica i Biologia Molecular, Facultat de Biociències, Universitat Autònoma de Barcelona, 08193-Bellaterra, Spain. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Apoptosis Regulatory Proteins / physiology, toxicity Cell Death / immunology Cells, Cultured Cerebellum / enzymology, immunology, pathology Dose-Response Relationship, Immunologic Eosinophil Cationic Protein / physiology*, toxicity Eosinophils / enzymology*, immunology, pathology* Humans Neurotoxins / toxicity Rats |
| Chemical | |
Reg. No./Substance:
|
0/Apoptosis Regulatory Proteins; 0/Neurotoxins; EC 3.1.27.-/Eosinophil Cationic Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Androgens suppress antigen-specific T cell responses and IFN-gamma production during intracranial LC...
Next Document: Quantitative evaluation of right atrial volume and right atrial emptying fraction by 320-slice compu...