Document Detail


Eosinophil-derived cytokines in health and disease: unraveling novel mechanisms of selective secretion.
MedLine Citation:
PMID:  23347072     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Over the past two decades, our understanding of eosinophils has evolved from that of categorically destructive effector cells to include active participation in immune modulation, tissue repair processes, and normal organ development, in both health and disease. At the core of their newly appreciated functions is the capacity of eosinophils to synthesize, store within intracellular granules, and very rapidly secrete a highly diverse repertoire of cytokines. Mechanisms governing the selective secretion of preformed cytokines from eosinophils are attractive therapeutic targets and may well be more broadly applicable to other immune cells. Here, we discuss recent advances in deciphering pathways of cytokine secretion, both from intact eosinophils and from tissue-deposited cell-free eosinophil granules, extruded from eosinophils undergoing a lytic cell death.
Authors:
R C N Melo; L Liu; J J Xenakis; L A Spencer
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2013-01-25
Journal Detail:
Title:  Allergy     Volume:  68     ISSN:  1398-9995     ISO Abbreviation:  Allergy     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-12     Completed Date:  2013-08-01     Revised Date:  2014-03-06    
Medline Journal Info:
Nlm Unique ID:  7804028     Medline TA:  Allergy     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  274-84     Citation Subset:  IM    
Copyright Information:
© 2013 John Wiley & Sons A/S. Published by Blackwell Publishing Ltd.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Cell Degranulation / immunology
Cytokines / immunology,  secretion*
Cytotoxicity, Immunologic
Eosinophils / immunology*,  metabolism*
Humans
Immunity, Innate
Secretory Vesicles / immunology,  metabolism,  ultrastructure
Signal Transduction
Grant Support
ID/Acronym/Agency:
AI020241/AI/NIAID NIH HHS; HL095699/HL/NHLBI NIH HHS; R01 AI020241/AI/NIAID NIH HHS; R01 HL095699/HL/NHLBI NIH HHS; R37 AI020241/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Cytokines
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Supramolecular Hydrogels from in situ Host-Guest Inclusion between Chemically Modified Cellulose Nan...
Next Document:  Development of the Thai healthy aging model: A grounded theory study.