Document Detail


Eosinophil cationic protein: A new biomarker of coronary atherosclerosis.
MedLine Citation:
PMID:  20307883     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIMS: Coronary atherosclerosis is a chronic inflammatory disease, but different inflammatory biomarkers may reflect different phases of atherosclerotic plaque evolution. We aimed at assessing the role of eosinophil cationic protein (ECP), a sensitive marker of eosinophil activation, and C-reactive protein (CRP) in coronary artery disease (CAD).
METHODS AND RESULTS: Consecutive anginal patients with angiographic evidence of CAD [stable angina (SA) or non-ST-elevation acute coronary syndrome (NSTE-ACS)], or with angiographically normal coronary arteries (NCA) were enrolled. The severity of CAD was graded according to Bogaty's score and coronary lesion morphology was defined as smooth or complex. Baseline ECP and high sensitivity CRP were measured in all patients. Of 198 patients (64 + or - 10 years, male 74%), 91 had SA, 57 had NSTE-ACS and 50 had NCA. ECP levels were significantly higher in SA [30 microg/L (13.8-46.9), p<0.001] and NSTE-ACS [21.8 microg/L (5.5-46.3), p=0.016] compared to NCA [9.7 microg/L (6.1-13.6)], without significant difference between SA and NSTE-ACS (p=0.45). CRP levels were significantly higher in NSTE-ACS [2.38 mg/L (1.11-11.94)] compared to SA [1.48 mg/L (0.82-2.83), p=0.03], and NCA [1.09 mg/L (0.8-2.1), p<0.001], without significant difference between SA and NCA (p=0.20). The addition of ECP to main cardiovascular risk factors improved the area under the curve from 0.88 to 0.92, p=0.007 for the angiographic diagnosis of CAD; further addition of CRP increased the area to 0.94, p=0.014. At multiple linear regression analysis ECP levels independently predicted CAD severity (p=0.001), whereas CRP levels independently predicted lesion complexity (p=0.01).
CONCLUSIONS: Our study shows that ECP is a marker of CAD and that different inflammatory biomarkers reflect different phases of atherosclerotic plaque evolution.
Authors:
Giampaolo Niccoli; Giuseppe Ferrante; Nicola Cosentino; Micaela Conte; Flavia Belloni; Marcello Marino; Marco Bacà; Rocco Antonio Montone; Vito Sabato; Domenico Schiavino; Giampiero Patriarca; Filippo Crea
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Publication Detail:
Type:  Journal Article     Date:  2010-03-04
Journal Detail:
Title:  Atherosclerosis     Volume:  211     ISSN:  1879-1484     ISO Abbreviation:  Atherosclerosis     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-08-02     Completed Date:  2010-12-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  606-11     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Ireland Ltd. All rights reserved.
Affiliation:
Institute of Cardiology, Catholic University of the Sacred Heart, Largo Agostino Gemelli 8, 00168 Rome, Italy. gniccoli73@hotmail.it
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MeSH Terms
Descriptor/Qualifier:
Acute Coronary Syndrome / blood
Aged
Biological Markers / metabolism*
Body Mass Index
C-Reactive Protein / metabolism
Coronary Artery Disease / blood*
Eosinophil Cationic Protein / blood*
Female
Humans
Inflammation
Male
Middle Aged
Plaque, Atherosclerotic / pathology
Risk Factors
Chemical
Reg. No./Substance:
0/Biological Markers; 9007-41-4/C-Reactive Protein; EC 3.1.27.-/Eosinophil Cationic Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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