Document Detail

Eomesodermin induces Mesp1 expression and cardiac differentiation from embryonic stem cells in the absence of Activin.
MedLine Citation:
PMID:  22402664     Owner:  NLM     Status:  MEDLINE    
The transcription factor Eomesodermin (Eomes) is involved in early embryonic patterning, but the range of cell fates that it controls as well as its mechanisms of action remain unclear. Here we show that transient expression of Eomes promotes cardiovascular fate during embryonic stem cell differentiation. Eomes also rapidly induces the expression of Mesp1, a key regulator of cardiovascular differentiation, and directly binds to regulatory sequences of Mesp1. Eomes effects are strikingly modulated by Activin signalling: high levels of Activin inhibit the promotion of cardiac mesoderm by Eomes, while they enhance Eomes-dependent endodermal specification. These results place Eomes upstream of the Mesp1-dependent programme of cardiogenesis, and at the intersection of mesodermal and endodermal specification, depending on the levels of Activin/Nodal signalling.
Jelle van den Ameele; Luca Tiberi; Antoine Bondue; Catherine Paulissen; Adèle Herpoel; Michelina Iacovino; Michael Kyba; Cédric Blanpain; Pierre Vanderhaeghen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  EMBO reports     Volume:  13     ISSN:  1469-3178     ISO Abbreviation:  EMBO Rep.     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-05-08     Completed Date:  2012-08-10     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  100963049     Medline TA:  EMBO Rep     Country:  England    
Other Details:
Languages:  eng     Pagination:  355-62     Citation Subset:  IM    
IRIBHM (Institute for Interdisciplinary Research), Université Libre de Bruxelles, Campus Erasme, Brussels B-1070, Belgium.
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MeSH Terms
Basic Helix-Loop-Helix Transcription Factors / genetics*,  metabolism
Cell Differentiation / drug effects*,  genetics
Embryonic Stem Cells / cytology*,  drug effects,  metabolism
Gene Expression Regulation / drug effects*
Mesoderm / cytology,  metabolism
Myocardium / cytology*
Organogenesis / drug effects
Promoter Regions, Genetic / genetics
Protein Binding / drug effects
Signal Transduction / drug effects,  genetics
T-Box Domain Proteins / genetics,  metabolism*
Grant Support
Reg. No./Substance:
0/Basic Helix-Loop-Helix Transcription Factors; 0/Eomes protein, mouse; 0/Mesp1 protein, mouse; 0/T-Box Domain Proteins; 104625-48-1/Activins

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