| Enzymic formation of dehydrogenated and hydroxylated metabolites from lysergic acid diethylamide by rat liver microsomes. | |
| | |
MedLine Citation:
|
PMID: 7415216 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
1. The metabolism of lysergic acid diethylamide (LSD) was studied using rat liver microsomes, and two minor metabolites were obtained in addition to lysergic acid ethylamide and N6-desmethyl-lysergic acid diethylamide (nor-LSD) which were reported previously. 2. One of the metabolites was identified as lysergic acid ethylvinylamide, apparently formed by dehydrogenation of a diethylamide group in the side chain at the 8-position, and the other as the phenol 13-hydroxy-LSD. 3. The formation of both lysergic acid ethylamide and lysergic acid ethylvinylamide was similarly induced by pretreatment of rats with either phenobarbitone sodium or 3-methylcholanthrene, while nor-LSD formation was induced only by phenobarbitone and that of 13-hydroxy-LSD only by methylcholanthrene. |
| | |
Authors:
|
T Inoue; T Niwaguchi; T Murata |
Related Documents
:
|
7268636 - Effect of retinoic acid upon the chick embryonic morphogenetic systems. i. the embryoto... 11953746 - Genetic evidence that oxidative derivatives of retinoic acid are not involved in retino... 2275606 - Vitamin a supplementation increases levels of retinoic acid compounds in human plasma: ... 4295866 - Biosynthesis of beta-glucuronides of retinol and of retinoic acid in vivo and in vitro. 18255286 - Development of mesoporosity during phosphoric acid activation of wood in steam atmosphere. 7249556 - Regulation of 25-hydroxy-vitamin d-1 alpha-hydroxylase in chick isolated renal tubules:... |
Publication Detail:
|
Type: In Vitro; Journal Article |
Journal Detail:
|
Title: Xenobiotica; the fate of foreign compounds in biological systems Volume: 10 ISSN: 0049-8254 ISO Abbreviation: Xenobiotica Publication Date: 1980 May |
Date Detail:
|
Created Date: 1980-11-20 Completed Date: 1980-11-20 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 1306665 Medline TA: Xenobiotica Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 343-8 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Anaerobiosis Animals Biotransformation Hydroxylation Lysergic Acid Diethylamide / metabolism* Male Methylcholanthrene / pharmacology Microsomes, Liver / metabolism* NAD / metabolism NADP / metabolism Oxidation-Reduction Phenobarbital / pharmacology Rats |
| Chemical | |
Reg. No./Substance:
|
50-06-6/Phenobarbital; 50-37-3/Lysergic Acid Diethylamide; 53-59-8/NADP; 53-84-9/NAD; 56-49-5/Methylcholanthrene |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Phenaceturic acid, a new urinary metabolite of styrene in the rat.
Next Document: Xenobiotic triglyceride formation.