Document Detail


ENZYMIC CONVERSION OF 3-HYDROXYANTHRANILIC ACID INTO CINNABARINIC ACID BY THE NUCLEAR FRACTION OF RAT LIVER.
MedLine Citation:
PMID:  14342496     Owner:  NLM     Status:  OLDMEDLINE    
Abstract/OtherAbstract:
1. An enzyme solely localized in the nuclear fraction of rat liver was found to convert 3-hydroxyanthranilic acid into a red product that was isolated and crystallized from the reaction mixture. The product was identified as cinnabarinic acid (2-amino-3-oxo-3H-phenoxazine-1,9-dicarboxylic acid) by comparing its properties with synthetic cinnabarinic acid. 2. The enzyme had optimum pH at 7.2. Heavy-metal ions like Ag(+), Hg(2+), MoO(4) (2-), Fe(2+) and Cu(2+) were inhibitory; Mn(2+) activated the reaction to a considerable extent. 3. The reaction was inhibited by mercaptoethanol, GSH and cysteine, and activated by p-hydroxymercuribenzoate and sodium arsenite, which may suggest the involvement of disulphide groups in the reaction.
Authors:
P V SUBBARAO; N S JEGANNATHAN; C S VAIDYANATHAN
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Biochemical journal     Volume:  95     ISSN:  0264-6021     ISO Abbreviation:  Biochem. J.     Publication Date:  1965 Jun 
Date Detail:
Created Date:  1965-12-01     Completed Date:  1996-12-01     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2984726R     Medline TA:  Biochem J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  628-32     Citation Subset:  OM    
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MeSH Terms
Descriptor/Qualifier:
Anthranilic Acids
Arsenicals*
Benzoates*
Cell Nucleus*
Copper*
Cysteine*
Enzyme Inhibitors*
Glutathione*
Iron*
Liver / cytology*,  enzymology*,  physiology*
Mercury*
Metabolism*
Molybdenum*
Oxazines*
Oxidoreductases*
Pharmacology*
Rats*
Research*
Silver*
Chemical
Reg. No./Substance:
0/Anthranilic Acids; 0/Arsenicals; 0/Benzoates; 0/Enzyme Inhibitors; 0/Oxazines; 118-92-3/anthranilic acid; 52-90-4/Cysteine; 70-18-8/Glutathione; 7439-89-6/Iron; 7439-97-6/Mercury; 7439-98-7/Molybdenum; 7440-22-4/Silver; 7440-50-8/Copper; EC 1.-/Oxidoreductases
Comments/Corrections

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