Document Detail

Enzymes involved in osmolyte synthesis: how does oxidative stress affect osmoregulation in renal cells?
MedLine Citation:
PMID:  20727361     Owner:  NLM     Status:  MEDLINE    
Kidney medulla cells are exposed to a wide range of changes in the ionic and osmotic composition of their environment as a consequence of the urine concentrating mechanism. During antidiuresis NaCl and urea concentrations increase and an efficient urinary concentrating mechanism is accompanied by medullar hypoxia. Medullar hypotonicity increases reactive oxygen species, a byproduct of mitochondria during ATP production. High intracellular ionic strength, hypoxia and elevated ROS concentration would have deleterious effects on medulla cell function. Medulla cells respond to hypertonicity by accumulating organic osmolytes, such as glycine betaine, glycerophosphorylcholine, sorbitol, inositol, and taurine, the main functions of which are osmoregulation and osmoprotection. The accumulation of compatible osmolytes is thus crucial for the viability of renal medulla cells. Studies about the effects of reactive oxygen species (ROS) on the enzymes involved in the synthesis of osmolytes are scarce. In this review we summarize the information available on the effects of ROS on the enzymes involved in osmolyte synthesis in kidney.
Jesús A Rosas-Rodríguez; Elisa M Valenzuela-Soto
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2010-08-18
Journal Detail:
Title:  Life sciences     Volume:  87     ISSN:  1879-0631     ISO Abbreviation:  Life Sci.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-18     Completed Date:  2010-11-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  515-20     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Inc. All rights reserved.
Centro de Investigación en Alimentación y Desarrollo A.C., Apartado Postal 1735, Hermosillo, Sonora, México.
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MeSH Terms
Aldehyde Reductase / metabolism
Betaine / metabolism
Kidney Medulla / cytology*,  enzymology*
Oxidative Stress / physiology*
Reactive Oxygen Species / metabolism
Water-Electrolyte Balance / physiology*
Reg. No./Substance:
0/Reactive Oxygen Species; 107-43-7/Betaine; EC Reductase

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