Document Detail

Enzymes in jasmonate biosynthesis - structure, function, regulation.
MedLine Citation:
PMID:  19703696     Owner:  NLM     Status:  MEDLINE    
Jasmonates are a growing class of lipid-derived signaling molecules with diverse functions ranging from the initiation of biotic and abiotic stress responses to the regulation of plant growth and development. Jasmonate biosynthesis originates from polyunsaturated fatty acids in chloroplast membranes. In a first lipoxygenase-catalyzed reaction molecular oxygen is introduced to yield their 13-hydroperoxy derivatives. These fatty acid hydroperoxides are converted by allene oxide synthase and allene oxide cyclase to 12-oxophytodienoic acid (OPDA) and dinor-OPDA, i.e. the first cyclic intermediates of the pathway. In the subsequent step, the characteristic cyclopentanone ring structure of jasmonates is established by OPDA reductase. Until recently, jasmonic acid has been viewed as the end product of the pathway and as the bioactive hormone. It becomes increasingly clear, however, that biological activity extends to and may even differ between the various jasmonic acid metabolites and conjugates as well as its biosynthetic precursors. It has also become clear that oxygenated fatty acids give rise to a vast variety of bioactive compounds including but not limited to jasmonates. Recent insights into the structure, function, and regulation of the enzymes involved in jasmonate biosynthesis help to explain how this variety is generated while specificity is maintained.
Andreas Schaller; Annick Stintzi
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Publication Detail:
Type:  Journal Article; Review     Date:  2009-08-22
Journal Detail:
Title:  Phytochemistry     Volume:  70     ISSN:  1873-3700     ISO Abbreviation:  Phytochemistry     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-10-30     Completed Date:  2010-01-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0151434     Medline TA:  Phytochemistry     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1532-8     Citation Subset:  IM    
Institute of Plant Physiology and Biotechnology, University of Hohenheim, D-70599 Stuttgart, Germany.
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MeSH Terms
Cyclopentanes / metabolism*
Gene Expression Regulation, Enzymologic
Gene Expression Regulation, Plant*
Intramolecular Oxidoreductases / chemistry,  metabolism
Models, Biological
Oxylipins / metabolism*
Plant Proteins / chemistry,  metabolism
Plants / enzymology*,  metabolism*
Substrate Specificity
Reg. No./Substance:
0/Cyclopentanes; 0/Oxylipins; 0/Plant Proteins; 6894-38-8/jasmonic acid; EC 5.3.-/Intramolecular Oxidoreductases; EC isomerase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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