Document Detail

Enzymes of glucose and fatty acid metabolism of liver, kidney, skeletal muscle, adipose tissue and mammary gland of lactating and non-lactating sheep.
MedLine Citation:
PMID:  3583945     Owner:  NLM     Status:  MEDLINE    
The effect of peak lactation on the activities of a number of enzymes of glucose and lipid metabolism of perirenal and subcutaneous adipose tissue, skeletal muscle, liver, kidney cortex and mammary parenchyma of sheep are described. Enzymes studied included hexokinase (glucose utilization), pyruvate carboxylase (gluconeogenesis), pyruvate dehydrogenase (glucose oxidation and production of acetyl CoA for fatty acid synthesis), acetyl CoA carboxylase (fatty acid synthesis) and glycerol-3-phosphate acyltransferase (fatty acid esterification). Major changes that were found include a decrease in activities of enzymes of fatty acid synthesis and esterification in adipose tissues, decreased activity of pyruvate dehydrogenase in muscle and adipose tissues and increased pyruvate carboxylase; there was no change in activities of enzyme of fatty acid esterification in liver. Activities of hexokinase, acetyl CoA carboxylase and glycerol-3-phosphate acyltransferase have been estimated per tissue; this shows the quantitative importance of limiting glucose utilization by muscle and of suppression of fatty acid synthesis in adipose tissue for efficient partitioning of nutrients for milk production.
R G Vernon; A Faulkner; E Finley; H Pollock; E Taylor
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of animal science     Volume:  64     ISSN:  0021-8812     ISO Abbreviation:  J. Anim. Sci.     Publication Date:  1987 May 
Date Detail:
Created Date:  1987-06-30     Completed Date:  1987-06-30     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8003002     Medline TA:  J Anim Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1395-411     Citation Subset:  IM    
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MeSH Terms
Adipose Tissue / enzymology*,  metabolism
Fatty Acids / metabolism*
Glucose / metabolism*
Kidney / enzymology*,  metabolism
Lactation / metabolism
Liver / enzymology*,  metabolism
Mammary Glands, Animal / enzymology*,  metabolism
Muscles / enzymology*,  metabolism
Sheep / metabolism*
Reg. No./Substance:
0/Fatty Acids; 50-99-7/Glucose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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