| Enzymes of glucose and fatty acid metabolism of liver, kidney, skeletal muscle, adipose tissue and mammary gland of lactating and non-lactating sheep. | |
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MedLine Citation:
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PMID: 3583945 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of peak lactation on the activities of a number of enzymes of glucose and lipid metabolism of perirenal and subcutaneous adipose tissue, skeletal muscle, liver, kidney cortex and mammary parenchyma of sheep are described. Enzymes studied included hexokinase (glucose utilization), pyruvate carboxylase (gluconeogenesis), pyruvate dehydrogenase (glucose oxidation and production of acetyl CoA for fatty acid synthesis), acetyl CoA carboxylase (fatty acid synthesis) and glycerol-3-phosphate acyltransferase (fatty acid esterification). Major changes that were found include a decrease in activities of enzymes of fatty acid synthesis and esterification in adipose tissues, decreased activity of pyruvate dehydrogenase in muscle and adipose tissues and increased pyruvate carboxylase; there was no change in activities of enzyme of fatty acid esterification in liver. Activities of hexokinase, acetyl CoA carboxylase and glycerol-3-phosphate acyltransferase have been estimated per tissue; this shows the quantitative importance of limiting glucose utilization by muscle and of suppression of fatty acid synthesis in adipose tissue for efficient partitioning of nutrients for milk production. |
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Authors:
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R G Vernon; A Faulkner; E Finley; H Pollock; E Taylor |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of animal science Volume: 64 ISSN: 0021-8812 ISO Abbreviation: J. Anim. Sci. Publication Date: 1987 May |
Date Detail:
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Created Date: 1987-06-30 Completed Date: 1987-06-30 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8003002 Medline TA: J Anim Sci Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1395-411 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adipose Tissue
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enzymology*,
metabolism Animals Fatty Acids / metabolism* Female Glucose / metabolism* Kidney / enzymology*, metabolism Lactation / metabolism Liver / enzymology*, metabolism Mammary Glands, Animal / enzymology*, metabolism Muscles / enzymology*, metabolism Pregnancy Sheep / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids; 50-99-7/Glucose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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