Document Detail

Enzyme polymorphisms, smoking, and human reproduction. A study of human placental alkaline phosphatase.
MedLine Citation:
PMID:  14595869     Owner:  NLM     Status:  MEDLINE    
We investigated the possible effects of placental alkaline phosphatase (PLAP) genotype on the deleterious action of maternal smoke on intrauterine survival and birthweight. PLAP is a highly polymorphic enzyme with several alleles associated with different enzymatic activities. PLAP is produced by the embryo and is found in maternal blood, where it is responsible for the rise of serum alkaline phosphatase during pregnancy. Two hundred and fourteen Caucasian consecutive newborn infants delivered in the Maternity Department of the University of Rome La Sapienza Hospital were studied. Infants from smoking women 28 years or older show a strong decrease of both PLAP*1/*1 and *2/*2 homozygous types and a marked deviation from Hardy-Weinberg expectation, thus suggesting a different lethal effect of smoke depending on PLAP genotype and maternal age. In infants from smoking mothers there is a decrease of birthweight that is much less evident and statistically not significant in infants carrying the PLAP*1/*1 genotype as compared to other genotypes. The difference between PLAP genotypes concerning birthweight is more marked in women older than 28 years than in younger ones. This suggests that the effects of smoke on birthweight are also dependent on PLAP and maternal age.
A Magrini; N Bottini; F Gloria-Bottini; L Stefanini; A Bergamaschi; E Cosmi; E Bottini
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of human biology : the official journal of the Human Biology Council     Volume:  15     ISSN:  1042-0533     ISO Abbreviation:  Am. J. Hum. Biol.     Publication Date:    2003 Nov-Dec
Date Detail:
Created Date:  2003-11-03     Completed Date:  2004-03-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8915029     Medline TA:  Am J Hum Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  781-5     Citation Subset:  IM    
Copyright Information:
Copyright 2003 Wiley-Liss, Inc.
Department of Biopathology and Imaging Diagnostics, University of Rome Tor Vergata, School of Medicine, Rome, Italy.
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MeSH Terms
Alkaline Phosphatase / genetics*,  metabolism
Birth Weight*
Fetal Death / etiology*
Infant, Newborn
Maternal Age
Placenta / enzymology*
Polymorphism, Genetic*
Smoking / adverse effects*
Reg. No./Substance:
EC Phosphatase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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