| Enzyme- and immunohistochemical localization of nitric oxide synthase in nerves of the porcine pancreas. | |
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MedLine Citation:
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PMID: 11018302 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The distribution of nitric oxide synthase (NOS) in neuronal and non-neuronal porcine pancreatic tissues was examined using nicotinamide adenine dinucleotide hydrogen phosphate diaphorase (NADPHd) enzymehistochemistry and neuronal type NOS immunohistochemistry. NOS-containing perikarya were regularly discernible in the pancreatic ganglia, whereas positive thin nerve fibers appeared within nerve bundles of the interlobular spaces and as thin varicose fibers in the vicinity of pancreatic blood vessels. Vascular endothelium showed intense staining for NADPHd and most of the islet cells were NOS immunoreactive. The above morphological findings indicate that nitrergic innervation of the porcine pancreas is very similar to that of the pancreata of other mammalian species and suggest that nitric oxide of both neuronal and extraneuronal origin may regulate blood flow and secretion of the porcine pancreas. |
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Authors:
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Z Ember; A Réti; E Fehér |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Neuroscience letters Volume: 292 ISSN: 0304-3940 ISO Abbreviation: Neurosci. Lett. Publication Date: 2000 Oct |
Date Detail:
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Created Date: 2000-10-23 Completed Date: 2000-11-09 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7600130 Medline TA: Neurosci Lett Country: IRELAND |
Other Details:
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Languages: eng Pagination: 163-6 Citation Subset: IM |
Affiliation:
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Semmelweis University, Faculty of Medicine, Department of Anatomy, Histology and Embryology, P.O. Box 95, 1450, Budapest, Hungary. ember@ana.sote.hu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Vessels / cytology, enzymology, innervation Endothelium, Vascular / cytology, enzymology Immunohistochemistry Islets of Langerhans / cytology, enzymology Male NADPH Dehydrogenase / metabolism Neurons / cytology, enzymology Nitric Oxide Synthase / metabolism* Nitric Oxide Synthase Type I Pancreas / cytology, enzymology*, innervation* Peripheral Nerves / cytology, enzymology* Swine |
| Chemical | |
Reg. No./Substance:
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EC 1.14.13.39/Nitric Oxide Synthase; EC 1.14.13.39/Nitric Oxide Synthase Type I; EC 1.6.99.1/NADPH Dehydrogenase |
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