Document Detail

Enzyme- and immunohistochemical localization of nitric oxide synthase in nerves of the porcine pancreas.
MedLine Citation:
PMID:  11018302     Owner:  NLM     Status:  MEDLINE    
The distribution of nitric oxide synthase (NOS) in neuronal and non-neuronal porcine pancreatic tissues was examined using nicotinamide adenine dinucleotide hydrogen phosphate diaphorase (NADPHd) enzymehistochemistry and neuronal type NOS immunohistochemistry. NOS-containing perikarya were regularly discernible in the pancreatic ganglia, whereas positive thin nerve fibers appeared within nerve bundles of the interlobular spaces and as thin varicose fibers in the vicinity of pancreatic blood vessels. Vascular endothelium showed intense staining for NADPHd and most of the islet cells were NOS immunoreactive. The above morphological findings indicate that nitrergic innervation of the porcine pancreas is very similar to that of the pancreata of other mammalian species and suggest that nitric oxide of both neuronal and extraneuronal origin may regulate blood flow and secretion of the porcine pancreas.
Z Ember; A Réti; E Fehér
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neuroscience letters     Volume:  292     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  2000 Oct 
Date Detail:
Created Date:  2000-10-23     Completed Date:  2000-11-09     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  163-6     Citation Subset:  IM    
Semmelweis University, Faculty of Medicine, Department of Anatomy, Histology and Embryology, P.O. Box 95, 1450, Budapest, Hungary.
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MeSH Terms
Blood Vessels / cytology,  enzymology,  innervation
Endothelium, Vascular / cytology,  enzymology
Islets of Langerhans / cytology,  enzymology
NADPH Dehydrogenase / metabolism
Neurons / cytology,  enzymology
Nitric Oxide Synthase / metabolism*
Nitric Oxide Synthase Type I
Pancreas / cytology,  enzymology*,  innervation*
Peripheral Nerves / cytology,  enzymology*
Reg. No./Substance:
EC Oxide Synthase; EC Oxide Synthase Type I; EC Dehydrogenase

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