| Enzyme-free nucleic acid logic circuits. | |
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MedLine Citation:
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PMID: 17158324 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Biological organisms perform complex information processing and control tasks using sophisticated biochemical circuits, yet the engineering of such circuits remains ineffective compared with that of electronic circuits. To systematically create complex yet reliable circuits, electrical engineers use digital logic, wherein gates and subcircuits are composed modularly and signal restoration prevents signal degradation. We report the design and experimental implementation of DNA-based digital logic circuits. We demonstrate AND, OR, and NOT gates, signal restoration, amplification, feedback, and cascading. Gate design and circuit construction is modular. The gates use single-stranded nucleic acids as inputs and outputs, and the mechanism relies exclusively on sequence recognition and strand displacement. Biological nucleic acids such as microRNAs can serve as inputs, suggesting applications in biotechnology and bioengineering. |
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Authors:
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Georg Seelig; David Soloveichik; David Yu Zhang; Erik Winfree |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Science (New York, N.Y.) Volume: 314 ISSN: 1095-9203 ISO Abbreviation: Science Publication Date: 2006 Dec |
Date Detail:
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Created Date: 2006-12-12 Completed Date: 2006-12-19 Revised Date: 2007-03-19 |
Medline Journal Info:
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Nlm Unique ID: 0404511 Medline TA: Science Country: United States |
Other Details:
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Languages: eng Pagination: 1585-8 Citation Subset: IM |
Affiliation:
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Department of Applied Physics, California Institute of Technology, Pasadena, CA 91125, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Base Pairing Base Sequence Biotechnology* Computers, Molecular* DNA* DNA, Single-Stranded* Logic Mice MicroRNAs Nanostructures Nucleic Acid Conformation Oligodeoxyribonucleotides |
| Chemical | |
Reg. No./Substance:
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0/DNA, Single-Stranded; 0/MicroRNAs; 0/Oligodeoxyribonucleotides; 9007-49-2/DNA |
| Comments/Corrections | |
Comment In:
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Science. 2006 Dec 8;314(5805):1552-3
[PMID:
17158311
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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