| Enzyme activity of macrophage migration inhibitory factor toward oxidized catecholamines. | |
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MedLine Citation:
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PMID: 9920865 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Macrophage migration inhibitory factor (MIF) is a relatively small, 12.5-kDa protein that is structurally related to some isomerases and for which multiple immune and catalytic roles have been proposed. MIF is widely expressed in tissues with particularly high levels in neural tissues. Here we show that MIF is able to catalyze the conversion of 3,4-dihydroxyphenylaminechrome and norepinephrinechrome, toxic quinone products of the neurotransmitter catecholamines 3,4-dihydroxyphenylamine and norepinephrine, to indoledihydroxy derivatives that may serve as precursors to neuromelanin. This raises the possibility that MIF participates in a detoxification pathway for catecholamine products and could therefore have a protective role in neural tissues, which as in Parkinson's disease, may be subject to catecholamine-related cell death. |
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Authors:
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J Matsunaga; D Sinha; L Pannell; C Santis; F Solano; G J Wistow; V J Hearing |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of biological chemistry Volume: 274 ISSN: 0021-9258 ISO Abbreviation: J. Biol. Chem. Publication Date: 1999 Feb |
Date Detail:
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Created Date: 1999-02-26 Completed Date: 1999-02-26 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 2985121R Medline TA: J Biol Chem Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 3268-71 Citation Subset: IM |
Affiliation:
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Pigment Cell Biology Section, Laboratory of Cell Biology, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aging
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metabolism Animals Base Sequence Brain / metabolism Catecholamines / metabolism* DNA Primers Humans Macrophage Migration-Inhibitory Factors / metabolism* Mice Oxidation-Reduction Recombinant Proteins / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Catecholamines; 0/DNA Primers; 0/Macrophage Migration-Inhibitory Factors; 0/Recombinant Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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