Document Detail


Enzyme activity of macrophage migration inhibitory factor toward oxidized catecholamines.
MedLine Citation:
PMID:  9920865     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Macrophage migration inhibitory factor (MIF) is a relatively small, 12.5-kDa protein that is structurally related to some isomerases and for which multiple immune and catalytic roles have been proposed. MIF is widely expressed in tissues with particularly high levels in neural tissues. Here we show that MIF is able to catalyze the conversion of 3,4-dihydroxyphenylaminechrome and norepinephrinechrome, toxic quinone products of the neurotransmitter catecholamines 3,4-dihydroxyphenylamine and norepinephrine, to indoledihydroxy derivatives that may serve as precursors to neuromelanin. This raises the possibility that MIF participates in a detoxification pathway for catecholamine products and could therefore have a protective role in neural tissues, which as in Parkinson's disease, may be subject to catecholamine-related cell death.
Authors:
J Matsunaga; D Sinha; L Pannell; C Santis; F Solano; G J Wistow; V J Hearing
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of biological chemistry     Volume:  274     ISSN:  0021-9258     ISO Abbreviation:  J. Biol. Chem.     Publication Date:  1999 Feb 
Date Detail:
Created Date:  1999-02-26     Completed Date:  1999-02-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  2985121R     Medline TA:  J Biol Chem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  3268-71     Citation Subset:  IM    
Affiliation:
Pigment Cell Biology Section, Laboratory of Cell Biology, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA.
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MeSH Terms
Descriptor/Qualifier:
Aging / metabolism
Animals
Base Sequence
Brain / metabolism
Catecholamines / metabolism*
DNA Primers
Humans
Macrophage Migration-Inhibitory Factors / metabolism*
Mice
Oxidation-Reduction
Recombinant Proteins / metabolism
Chemical
Reg. No./Substance:
0/Catecholamines; 0/DNA Primers; 0/Macrophage Migration-Inhibitory Factors; 0/Recombinant Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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