| Enzymatically active papain preferentially induces an allergic response in mice. | |
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MedLine Citation:
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PMID: 9918815 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Human exposure to papain, a cysteine proteinase, is associated with hypersensitivity reactions. We demonstrate in mice that enzymatically active papain preferentially induces an IgG1 response and results in mast cell degranulation, both features typical of an allergic reaction. Inactive papain, blocked with E-64, appears to desensitize mice to subsequent challenge by active enzyme. These results suggest that the enzymatic activity of papain is critical in inducing an allergic response and that the use of inactive allergens may be a possible strategy for desensitizing allergic individuals. |
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Authors:
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L Chambers; A Brown; D I Pritchard; S Sreedharan; K Brocklehurst; N A Kalsheker |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biochemical and biophysical research communications Volume: 253 ISSN: 0006-291X ISO Abbreviation: Biochem. Biophys. Res. Commun. Publication Date: 1998 Dec |
Date Detail:
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Created Date: 1999-02-09 Completed Date: 1999-02-09 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0372516 Medline TA: Biochem Biophys Res Commun Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 837-40 Citation Subset: IM |
Affiliation:
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Division of Clinical Chemistry, School of Clinical Laboratory Sciences, University Hospital, Nottingham, England. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Degranulation Cysteine Proteinase Inhibitors / pharmacology Hypersensitivity* Immunoglobulin G / blood Leucine / analogs & derivatives, pharmacology Male Mast Cells / immunology Mice Mice, Inbred BALB C Papain / antagonists & inhibitors, immunology*, isolation & purification Vaccination |
| Chemical | |
Reg. No./Substance:
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0/Cysteine Proteinase Inhibitors; 0/Immunoglobulin G; 61-90-5/Leucine; 66701-25-5/E 64; EC 3.4.22.2/Papain |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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