| Enzymatic versus pharmacologic antagonism of profound mivacurium- induced neuromuscular blockade. | |
| | |
MedLine Citation:
|
PMID: 8623998 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Mivacurium, a nondepolarizing muscle relaxant, is hydrolyzed by butyrylcholinesterase. The use of butyrylcholinesterase for antagonism of profound mivacurium-induced blockade has not been studied in humans. In part 1 of this two-part study, the authors examined the relationship between the posttetanic count (PTC) and recovery from profound mivacurium-induced blockade. In part 2, an attempt was made to antagonize a quantified level of profound mivacurium-induced blockade using either butyrylcholinesterase, edrophonium, or neostigmine. METHODS: Eighty-seven ASA physical status 1 or 2 adult patients were given 0.15 mg.kg-1 mivacurium during fentanyl-thiopental-nitrous oxide-isoflurane anesthesia. They were randomly assigned to eight groups. Neuromuscular function was monitored by recording the mechanomyographic response of the adductor pollicis to PTC and train-of-four (TOF) stimulation in all patients except those in group 1 where the TOF was the only pattern used. In part 1, neuromuscular function was allowed to recover spontaneously in ten patients (group 1; control-TOF) until TOF ratio (the amplitude of the fourth evoked response as a fraction of the first evoked response T4/T1) had reached 0.75. The temporal relationship between PTC and the first reaction to TOF stimulation was determined in another 31 patients, and neuromuscular function in 10 of these patients was allowed to recover spontaneously until TOF ratio had reached 0.75. The temporal relationship between PTC and the first reaction to TOF stimulation was determined in another 21 patients, and neuromuscular function in 10 of these patients was allowed to recover spontaneously, until TOF ratio had reached 0.75 (group 2; control-PTC). In part 2, the antagonism of mivacurium-induced profound (PTC > or = 1; groups 3-6) and 90% block (groups 7-8) of twitch height were investigated in another 56 patients. Groups 3 and 7 received neostigmine 0.06 mg.kg-1 whereas groups 4 and 8 received edrophonium 1 mg.kg-1, respectively. Groups 5 and 6 received exogenous human butyrylcholinesterase equivalent to activity present in 25 or 70 ml.kg-1 of human plasma, respectively. RESULTS: Neither butyrylcholinesterase nor edrophonium shortened the times from first PTC response to TOF = 0.75 compared to group 2. Neostigmine resulted in prolongation of recovery time. There was a linear relationship (r = -0.80; P = 0.00001) between PTC and time of onset of TOF response. CONCLUSIONS: There appears to be no clinical advantage in attempting to antagonize profound mivacurium-induced neuromuscular blockade. |
| | |
Authors:
|
M Naguib; M Selim; H S Bakhamees; A H Samarkandi; A Turkistani |
Related Documents
:
|
22238568 - Correction: following a foraging fish-finder: diel habitat use of blainville's beaked w... 20850348 - A prospective, randomized, double-blind trial of 3 regimens for sedation and analgesia ... 21048628 - Awake craniotomy versus general anesthesia for managing eloquent cortex low-grade gliomas. 8419248 - Subhypnotic doses of propofol relieve pruritus associated with liver disease. 9554388 - Modified lich-gregoir ureteral reimplantation: experience of a canadian center. 15111858 - Basilic vein transposition fistula: a good option for maintaining hemodialysis access s... |
Publication Detail:
|
Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
|
Title: Anesthesiology Volume: 84 ISSN: 0003-3022 ISO Abbreviation: Anesthesiology Publication Date: 1996 May |
Date Detail:
|
Created Date: 1996-06-14 Completed Date: 1996-06-14 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 1300217 Medline TA: Anesthesiology Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 1051-9 Citation Subset: AIM; IM |
Affiliation:
|
Department of Anaesthesiology, King Saud University, Faculty of Medicine, King Khalid University Hospital, Riyadh, Saudi Arabia. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Cholinesterases / blood, pharmacology Edrophonium / pharmacology Female Humans Isoquinolines / antagonists & inhibitors* Male Middle Aged Neostigmine / pharmacology Neuromuscular Junction / drug effects*, physiology Neuromuscular Nondepolarizing Agents / antagonists & inhibitors* |
| Chemical | |
Reg. No./Substance:
|
0/Isoquinolines; 0/Neuromuscular Nondepolarizing Agents; 106791-40-6/mivacurium; 312-48-1/Edrophonium; 59-99-4/Neostigmine; EC 3.1.1.8/Cholinesterases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Derivation and cross-validation of pharmacokinetic parameters for computer-controlled infusion of li...
Next Document: Parental presence during induction of anesthesia. A randomized controlled trial.