| Enzymatic synthesis of structured lipids. | |
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MedLine Citation:
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PMID: 15453189 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Structured lipids (SLs) are defined as lipids that are modified chemically or enzymatically in order to change their structure. This review deals with structured triacylglycerols (STGs) and structured phospholipids (SPLs). The most typical STGs are MLM-type STGs, having medium chain fatty acids (FAs) at the 1- and 3-positions and a long chain fatty acid at the 2- position. MLM-type STGs are synthesized by: 1) 1,3-position-specific lipase-catalyzed acyl exchange of TG with FA or with FA ethylester (FAEt); 2) 1,3-position-specific lipase-catalyzed acylation of glycerol with FA, giving symmetric 1,3-diacyl-sn-glycerol, followed by chemical acylation at the sn-2 position, and; 3) 1,3-position-specific lipase-catalyzed deacylation of TG, giving 2-monoacylglycerol, followed by reacylation at the 1- and 3-positions with FA or with (FAEt). Enzymatic preparation of SPLs requires: 1) acyl group modification, and 2) head group modification of phospholipids. Acyl group modification is performed using lipases or phospholipase A2-mediated transesterification or ester synthesis to introduce arbitrary fatty acid to phospholipids. Head group modification is carried out by phospholipase D-catalyzed transphosphatidylation. A wide range of compounds can be introduced into the polar head of phospholipids, making it possible to prepare various SPLs. |
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Authors:
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Yugo Iwasaki; Tsuneo Yamane |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Advances in biochemical engineering/biotechnology Volume: 90 ISSN: 0724-6145 ISO Abbreviation: Adv. Biochem. Eng. Biotechnol. Publication Date: 2004 |
Date Detail:
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Created Date: 2004-09-29 Completed Date: 2005-01-14 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8307733 Medline TA: Adv Biochem Eng Biotechnol Country: Germany |
Other Details:
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Languages: eng Pagination: 151-71 Citation Subset: IM |
Affiliation:
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Laboratory of Molecular Biotechnology, Graduate School of Bio- and Agro-Sciences, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Arbutin
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chemistry Enzymes / chemistry*, metabolism Fats / chemistry, metabolism Fatty Acids / chemistry, metabolism Fungi / enzymology Lipase / chemistry, metabolism Lipid Metabolism Lipids / chemical synthesis*, chemistry Molecular Structure N-Acetylneuraminic Acid / chemistry Nucleosides / chemistry Oils / chemistry, metabolism Phosphatidylserines / chemical synthesis, chemistry Phospholipases / chemistry, metabolism Phospholipids / chemical synthesis, chemistry, metabolism Pyrones / chemistry Triglycerides / chemical synthesis, chemistry, metabolism Vitamins / chemistry |
| Chemical | |
Reg. No./Substance:
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0/Enzymes; 0/Fats; 0/Fatty Acids; 0/Lipids; 0/Nucleosides; 0/Oils; 0/Phosphatidylserines; 0/Phospholipids; 0/Pyrones; 0/Triglycerides; 0/Vitamins; 131-48-6/N-Acetylneuraminic Acid; 497-76-7/Arbutin; 501-30-4/kojic acid; EC 3.1.-/Phospholipases; EC 3.1.1.3/Lipase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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