Document Detail

Enzymatic synthesis of cinnamic acid derivatives.
MedLine Citation:
PMID:  16614896     Owner:  NLM     Status:  MEDLINE    
Using Novozym 435 as catalyst, the syntheses of ethyl ferulate (EF) from ferulic acid (4-hydroxy 3-methoxy cinnamic acid) and ethanol, and octyl methoxycinnamate (OMC) from p-methoxycinnamic acid and 2-ethyl hexanol were successfully carried out in this study. A conversion of 87% was obtained within 2 days at 75 degrees C for the synthesis of EF. For the synthesis of OMC at 80 degrees C, 90% conversion can be obtained within 1 day. The use of solvent and high reaction temperature resulted in better conversion for the synthesis of cinnamic acid derivatives. Some cinnamic acid esters could also be obtained with higher conversion and shorter reaction times in comparison to other methods reported in the literature. The enzyme can be reused several times before significant activity loss was observed.
Gia-Sheu Lee; Arief Widjaja; Yi-Hsu Ju
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biotechnology letters     Volume:  28     ISSN:  0141-5492     ISO Abbreviation:  Biotechnol. Lett.     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-04-14     Completed Date:  2006-11-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8008051     Medline TA:  Biotechnol Lett     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  581-5     Citation Subset:  IM    
Department of Chemical Engineering, National Taiwan University of Science and Technology, 43 Keelung Road, Section 4, Taipei 106-07, Taiwan.
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MeSH Terms
Acrylic Resins / chemistry
Caffeic Acids / chemistry,  isolation & purification,  metabolism*
Chromatography, High Pressure Liquid
Cinnamates / chemistry,  isolation & purification,  metabolism*
Coumaric Acids / chemistry,  metabolism
Enzyme Stability
Enzymes, Immobilized / chemistry,  metabolism
Ethanol / chemistry,  metabolism
Hexanols / chemistry,  metabolism
Lipase / chemistry,  metabolism*
Time Factors
Water / chemistry,  metabolism
Reg. No./Substance:
0/Acrylic Resins; 0/Caffeic Acids; 0/Cinnamates; 0/Coumaric Acids; 0/Enzymes, Immobilized; 0/Hexanols; 0/octylmethoxycinnamate; 104-76-7/2-ethylhexanol; 1135-24-6/ferulic acid; 4046-02-0/ethyl ferulate; 621-82-9/cinnamic acid; 64-17-5/Ethanol; 7732-18-5/Water; 830-09-1/4-methoxycinnamic acid; EC 3.1.1.-/Novozyme 435; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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