| Enzymatic synthesis of L-pipecolic acid by Delta1-piperideine-2-carboxylate reductase from Pseudomonas putida. | |
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MedLine Citation:
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PMID: 16960365 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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L-Pipecolic acid is a chiral pharmaceutical intermediate. An enzymatic system for the synthesis of L-pipecolic acid from L-lysine by commercial L-lysine alpha-oxidase from Trichoderma viride and an extract of recombinant Escherichia coli cells coexpressing Delta1-piperideine-2-carboxylate reductase from Pseudomonas putida and glucose dehydrogenase from Bacillus subtilis is described. A laboratory-scale process provided 27 g/l of L-pipecolic acid in 99.7% e.e. |
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Authors:
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Hisashi Muramatsu; Hisaaki Mihara; Mari Yasuda; Makoto Ueda; Tatsuo Kurihara; Nobuyoshi Esaki |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2006-09-07 |
Journal Detail:
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Title: Bioscience, biotechnology, and biochemistry Volume: 70 ISSN: 0916-8451 ISO Abbreviation: Biosci. Biotechnol. Biochem. Publication Date: 2006 Sep |
Date Detail:
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Created Date: 2006-09-27 Completed Date: 2006-11-21 Revised Date: 2012-05-25 |
Medline Journal Info:
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Nlm Unique ID: 9205717 Medline TA: Biosci Biotechnol Biochem Country: Japan |
Other Details:
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Languages: eng Pagination: 2296-8 Citation Subset: IM |
Affiliation:
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Institute for Chemical Research, Kyoto University, Uji, Kyoto, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Bacillus subtilis
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enzymology Glucose 1-Dehydrogenase / metabolism Industrial Microbiology / methods* Mixed Function Oxygenases / metabolism Oxidoreductases Acting on CH-NH Group Donors / metabolism* Pipecolic Acids / metabolism* Pseudomonas putida / enzymology, metabolism* Trichoderma / enzymology |
| Chemical | |
Reg. No./Substance:
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0/Pipecolic Acids; 535-75-1/pipecolic acid; EC 1.-/Mixed Function Oxygenases; EC 1.1.1.47/Glucose 1-Dehydrogenase; EC 1.13.12.2/lysine monooxygenase; EC 1.5.-/Oxidoreductases Acting on CH-NH Group Donors; EC 1.5.1.21/1,2-didehydropipecolate reductase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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