Document Detail


Enzymatic synthesis of L-pipecolic acid by Delta1-piperideine-2-carboxylate reductase from Pseudomonas putida.
MedLine Citation:
PMID:  16960365     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
L-Pipecolic acid is a chiral pharmaceutical intermediate. An enzymatic system for the synthesis of L-pipecolic acid from L-lysine by commercial L-lysine alpha-oxidase from Trichoderma viride and an extract of recombinant Escherichia coli cells coexpressing Delta1-piperideine-2-carboxylate reductase from Pseudomonas putida and glucose dehydrogenase from Bacillus subtilis is described. A laboratory-scale process provided 27 g/l of L-pipecolic acid in 99.7% e.e.
Authors:
Hisashi Muramatsu; Hisaaki Mihara; Mari Yasuda; Makoto Ueda; Tatsuo Kurihara; Nobuyoshi Esaki
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-09-07
Journal Detail:
Title:  Bioscience, biotechnology, and biochemistry     Volume:  70     ISSN:  0916-8451     ISO Abbreviation:  Biosci. Biotechnol. Biochem.     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-09-27     Completed Date:  2006-11-21     Revised Date:  2012-05-25    
Medline Journal Info:
Nlm Unique ID:  9205717     Medline TA:  Biosci Biotechnol Biochem     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  2296-8     Citation Subset:  IM    
Affiliation:
Institute for Chemical Research, Kyoto University, Uji, Kyoto, Japan.
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MeSH Terms
Descriptor/Qualifier:
Bacillus subtilis / enzymology
Glucose 1-Dehydrogenase / metabolism
Industrial Microbiology / methods*
Mixed Function Oxygenases / metabolism
Oxidoreductases Acting on CH-NH Group Donors / metabolism*
Pipecolic Acids / metabolism*
Pseudomonas putida / enzymology,  metabolism*
Trichoderma / enzymology
Chemical
Reg. No./Substance:
0/Pipecolic Acids; 535-75-1/pipecolic acid; EC 1.-/Mixed Function Oxygenases; EC 1.1.1.47/Glucose 1-Dehydrogenase; EC 1.13.12.2/lysine monooxygenase; EC 1.5.-/Oxidoreductases Acting on CH-NH Group Donors; EC 1.5.1.21/1,2-didehydropipecolate reductase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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