Document Detail

Enzymatic synthesis of L-ascorbyl linoleate in organic media.
MedLine Citation:
PMID:  16284781     Owner:  NLM     Status:  MEDLINE    
A novel L-ascorbyl fatty acid ester, L-ascorbyl linoleate was successfully prepared by enzymatic esterification and transesterification in a non-aqueous medium using immobilized lipase as biocatalyst. Changes in enzymatic activity and product yield were studied for the following variable: the nature of the fatty acid, the fatty acid concentration and water content. The yield of synthesis for the C18 unsaturated fatty acids were higher than for the C18 saturated fatty acid. Initial enzyme concentration does not affect the equilibrium of the reaction. And the product yield (33.5%) in the transesterification was higher than that of the esterification (21.8%) at a high-substrate concentration 0.3 M. The medium water content was found to have a distinct influence on the L-ascorbyl linoleate synthesis.
Qingxun Song; Ying Zhao; Weiqin Xu; Wenyu Zhou; Dongzhi Wei
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-11-12
Journal Detail:
Title:  Bioprocess and biosystems engineering     Volume:  28     ISSN:  1615-7591     ISO Abbreviation:  Bioprocess Biosyst Eng     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-03-06     Completed Date:  2006-05-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  101088505     Medline TA:  Bioprocess Biosyst Eng     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  211-5     Citation Subset:  IM    
State Key Laboratory of Bioreactor Engineering, New Word Institute of Biotechnology, East China University of Science and Technology, Shanghai, 200237, PR China.
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MeSH Terms
Ascorbic Acid / analogs & derivatives*,  chemical synthesis,  chemistry*
Enzymes, Immobilized / chemistry
Linoleic Acid / chemistry*
Linoleic Acids / chemical synthesis*,  chemistry*
Lipase / chemistry*
Organic Chemicals / chemistry*
Solvents / chemistry*
Reg. No./Substance:
0/Enzymes, Immobilized; 0/Linoleic Acids; 0/Organic Chemicals; 0/Solvents; 0/ascorbyl linoleate; 112-63-0/methyl linoleate; 2197-37-7/Linoleic Acid; 50-81-7/Ascorbic Acid; EC 3.1.1.-/lipase B, Candida antarctica; EC

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