| Enzymatic strategies to detoxify gluten: implications for celiac disease. | |
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MedLine Citation:
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PMID: 21048862 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Celiac disease is a permanent intolerance to the gliadin fraction of wheat gluten and to similar barley and rye proteins that occurs in genetically susceptible subjects. After ingestion, degraded gluten proteins reach the small intestine and trigger an inappropriate T cell-mediated immune response, which can result in intestinal mucosal inflammation and extraintestinal manifestations. To date, no pharmacological treatment is available to gluten-intolerant patients, and a strict, life-long gluten-free diet is the only safe and efficient treatment available. Inevitably, this may produce considerable psychological, emotional, and economic stress. Therefore, the scientific community is very interested in establishing alternative or adjunctive treatments. Attractive and novel forms of therapy include strategies to eliminate detrimental gluten peptides from the celiac diet so that the immunogenic effect of the gluten epitopes can be neutralized, as well as strategies to block the gluten-induced inflammatory response. In the present paper, we review recent developments in the use of enzymes as additives or as processing aids in the food biotechnology industry to detoxify gluten. |
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Authors:
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Ivana Caputo; Marilena Lepretti; Stefania Martucciello; Carla Esposito |
Publication Detail:
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Type: Journal Article Date: 2010-10-07 |
Journal Detail:
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Title: Enzyme research Volume: 2010 ISSN: 2090-0414 ISO Abbreviation: Enzyme Res Publication Date: 2010 |
Date Detail:
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Created Date: 2010-11-04 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101536666 Medline TA: Enzyme Res Country: England |
Other Details:
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Languages: eng Pagination: 174354 Citation Subset: - |
Affiliation:
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Department of Chemistry, University of Salerno, 84084 Salerno, Italy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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