Document Detail

Enzymatic production of hydroperoxides of unsaturated fatty acids by injury of mammalian cells.
MedLine Citation:
PMID:  8640899     Owner:  NLM     Status:  MEDLINE    
Hydroperoxides of unsaturated fatty acids (LOOHs) are generated by homogenisation of liver tissue, but not if the liver is boiled before homogenisation. This observation indicates that the LOOHs are produced in an enzymatic reaction. This assumption is corroborated by an analysis of the reduction products of LOOHs by gas chromatography/mass spectrometry (GC/MS). A main part of LOOHs is derived from linoleic acid and not from arachidonic acid. Massive cell damage occurs by myocardial infarction or other severe injuries; these events were found to be connected with generation of LOOHs. We suspect--considering the above outlined experiment--that the LOOH production is also mainly caused in these cases by activation of enzymes and not--as postulated--by an autocatalytic process. Increased amounts of LOOHs are found in many chronic diseases, e.g. in rheuma, atherosclerosis or psoriasis, obviously caused by a gradual damage of cells. Thus, the common root of an increased LOOH level might be cell injury.
M Herold; G Spiteller
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Chemistry and physics of lipids     Volume:  79     ISSN:  0009-3084     ISO Abbreviation:  Chem. Phys. Lipids     Publication Date:  1996 Mar 
Date Detail:
Created Date:  1996-07-17     Completed Date:  1996-07-17     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0067206     Medline TA:  Chem Phys Lipids     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  113-21     Citation Subset:  IM    
Institut fuer Organische Chemie I, Universitaet Bayreuth, Germany.
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MeSH Terms
Aldehydes / chemistry,  metabolism
Fatty Acids, Unsaturated / chemistry,  metabolism*
Gas Chromatography-Mass Spectrometry
Hot Temperature
Lipid Peroxidation
Lipid Peroxides / chemistry,  metabolism*
Liver / enzymology,  injuries
Reg. No./Substance:
0/Aldehydes; 0/Fatty Acids, Unsaturated; 0/Lipid Peroxides

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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