Document Detail


Enzymatic production of cyclodextrins.
MedLine Citation:
PMID:  12226716     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cyclodextrins (CD) are enzymatically modified starches with a wide range of applications in food, pharmaceutical and chemical industries, agriculture and environmental engineering. They are produced from starch via enzymatic conversion using cyclodextrin glycosyl transferases (CGTases) and partly alpha-amylases. Due to its low solubility in water, separation and purification of beta-CD is relatively easy compared to alpha- and gamma-CD. In recent years more economic processes for gamma-CD and especially alpha-CD production have been developed using improved CGTases and downstream processing. New purification steps, e.g. affinity adsorption, may reduce the use of complexing agents. The implementation of thermostable CGTases can simplify the production process and increase the selectivity of the reaction. A tabular overview of alpha-CD production processes is presented.
Authors:
A Biwer; G Antranikian; E Heinzle
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2002-07-16
Journal Detail:
Title:  Applied microbiology and biotechnology     Volume:  59     ISSN:  0175-7598     ISO Abbreviation:  Appl. Microbiol. Biotechnol.     Publication Date:  2002 Sep 
Date Detail:
Created Date:  2002-09-12     Completed Date:  2002-12-10     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8406612     Medline TA:  Appl Microbiol Biotechnol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  609-17     Citation Subset:  IM    
Affiliation:
Department of Biochemical Engineering, Saarland University, PO BOX 15 11 50, 66041 Saarbruecken, Germany.
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MeSH Terms
Descriptor/Qualifier:
Bacillus / enzymology
Carbohydrate Sequence
Cyclodextrins / biosynthesis*,  metabolism
Glucosyltransferases / metabolism*
Molecular Sequence Data
Starch / metabolism
alpha-Amylases / metabolism*
Chemical
Reg. No./Substance:
0/Cyclodextrins; 9005-25-8/Starch; EC 2.4.1.-/Glucosyltransferases; EC 2.4.1.19/cyclomaltodextrin glucanotransferase; EC 3.2.1.1/alpha-Amylases

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