Document Detail

Enzymatic degradation of human skin dermis revealed by fluorescence and reflectance spectroscopy.
MedLine Citation:
PMID:  18575556     Owner:  NLM     Status:  MEDLINE    
Dermis is the major source of the fluorescence and light scattering of skin. Tumor-induced degradation of the dermis is expected to change the fluorescence and light scattering properties of skin. To investigate how these fluorescence and light scattering properties are changed, human skin dermis was degraded with enzymes to mimic tumor invasion. The enzymatic erosion process was investigated with fluorescence and reflectance spectroscopy. Dermis degradation by the enzymes resulted in a decrease in fluorescence emission and light scattering in the dermis. Fluorescence anisotropy, however, could not detect the change in the dermis induced by the enzyme treatments.
Ye Yuan; Patricia Relue
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Optics express     Volume:  16     ISSN:  1094-4087     ISO Abbreviation:  Opt Express     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-06-25     Completed Date:  2008-08-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101137103     Medline TA:  Opt Express     Country:  United States    
Other Details:
Languages:  eng     Pagination:  9857-68     Citation Subset:  IM    
Cellular Engineering Laboratory, The University of Toledo, Ohio 43606, USA.
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MeSH Terms
Dermis / chemistry*,  enzymology*
Dermoscopy / methods*
Endopeptidases / chemistry*,  metabolism*
Microscopy, Fluorescence / methods*
Spectrometry, Fluorescence / methods*
Reg. No./Substance:
EC 3.4.-/Endopeptidases; EC 3.4.99.-/dispase

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