| Enzymatic degradation of and bovine serum albumin release from starch-acetate films. | |
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MedLine Citation:
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PMID: 11888313 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of acetylation of potato starch on swelling, enzymatic degradation, and bovine serum albumin (BSA, molecular mass 68 kDa) release rate from polymer films was studied. Potato starch and potato starch acetates (SA), having a degree of substitution of 1.9 or 2.6, were investigated. Polymer films were incubated in phosphate buffer solution pH 7.4 in the absence and presence of enzymes (alpha-amylase, amyloglucosidase, esterase) or in human serum. The acetylation of potato starch decreased its swelling considerably. Increased acetylation of starch also considerably retarded its enzymatic degradation. Due to the decreased swelling and degradation of SA films, BSA was released much slower from SA films than from potato starch films, both in the presence and absence of enzymes. |
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Authors:
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Laura M Tuovinen; Soili H Peltonen; Tapani M Suortti; Nicholas J Crowther; Matti A Elomaa; Kristiina P Järvinen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biomacromolecules Volume: 3 ISSN: 1525-7797 ISO Abbreviation: Biomacromolecules Publication Date: 2002 Mar-Apr |
Date Detail:
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Created Date: 2002-03-12 Completed Date: 2002-07-23 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 100892849 Medline TA: Biomacromolecules Country: United States |
Other Details:
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Languages: eng Pagination: 284-90 Citation Subset: IM |
Affiliation:
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Department of Pharmaceutics, University of Kuopio, P.O. Box 1627, FIN-70211 Kuopio, Finland. laura.tuovinen@uku.fi |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Drug Carriers Esterases Glucan 1,4-alpha-Glucosidase Microscopy, Electron, Scanning Molecular Weight Serum Albumin, Bovine / chemistry* Starch / analogs & derivatives*, chemistry* alpha-Amylases |
| Chemical | |
Reg. No./Substance:
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0/Drug Carriers; 0/Serum Albumin, Bovine; 9005-25-8/Starch; 9045-28-7/starch acetate; EC 3.1.-/Esterases; EC 3.2.1.1/alpha-Amylases; EC 3.2.1.3/Glucan 1,4-alpha-Glucosidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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