Document Detail

Enzymatic changes in serum and tissues in fowl infected with a neurotropic-mesogenic strain of Newcastle disease virus.
MedLine Citation:
PMID:  18770205     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Chickens aged 6 weeks were inoculated intravenously with two strains of Newcastle disease virus: a mesogenic strain (MAJ) with relatively high neurotropism and a lentogenic strain (V5K7E1). The levels of several enzymes were determined in serum and in various tissues of the infected birds. A marked increase in lactic dehydrogenase (LDH) level in skeletal muscles and a decrease of LDH activity in liver were found in chickens infected with the MAJ strain. Differentiation of LDH isoenzymes by either heating or electrophoresis indicated a significant elevation of LDH 5 iso-enzyme in breast muscle and of LDH 1 in leg muscle, while the activity of LDH 1 in liver decreased. Similar changes were found in the activity of hydroxy butyrate dehydrogenase. Infection with the MAJ strain caused an increase of acid phosphatase activity in breast muscle, a marked decrease of alkaline phosphatase and malate dehydrogenase and an increase of glutamate-oxaloacetate transaminase activities in the intestine. These findings indicate the origin of the changes in enzyme levels found in serum. The possibility of metabolic changes in muscles and liver resulting from damage to the central nervous system is discussed. Inoculation of chickens with the lentogenic strain produced no significant change in the enzyme profile of tissues and serum.
B Rivetz; E Bogin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Avian pathology : journal of the W.V.P.A     Volume:  11     ISSN:  0307-9457     ISO Abbreviation:  Avian Pathol.     Publication Date:  1982  
Date Detail:
Created Date:  2008-09-04     Completed Date:  2008-09-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8210638     Medline TA:  Avian Pathol     Country:  England    
Other Details:
Languages:  eng     Pagination:  407-25     Citation Subset:  -    
Department of Biochemistry, Kimron Veterinary Institute, Israel.
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