Document Detail


Enzymatic alterations in Reye's syndrome: prognostic implications.
MedLine Citation:
PMID:  1110856     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Serial studies on serum enzyme and isoenzyme abnormalities in seven cases of Reye's syndrome were found to segregate patients into three categories of organ involvement. The patients with both extensive hepatic and previously unrecognized skeletal muscle involvement died despite therapeutic measures. The other two groups were characterized by enzyme and isoenzyme changes consistent with either predominantly muscular or hepatic involvement. The prognostic value of these abnormalities has been substantiated in subsequent cases of this syndrome. These findings suggest that those patients at greatest risk may be identified early, thus improving evaluation of the efficacy of specific therapeutic interventions in this disease.
Authors:
C R Roe; L B Schonberger; S H Gelbach; L A Wies; J B Sidbury
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Pediatrics     Volume:  55     ISSN:  0031-4005     ISO Abbreviation:  Pediatrics     Publication Date:  1975 Jan 
Date Detail:
Created Date:  1975-04-19     Completed Date:  1975-04-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  119-26     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Alanine Transaminase / blood*
Aspartate Aminotransferases / blood*
Brain Diseases / enzymology*
Child
Child, Preschool
Creatine Kinase / blood*
Humans
Infant
Isoenzymes / blood
L-Lactate Dehydrogenase / blood*
Liver / enzymology
Muscles / enzymology
Prognosis
Reye Syndrome / enzymology*
Virus Diseases / diagnosis,  enzymology
Chemical
Reg. No./Substance:
0/Isoenzymes; EC 1.1.1.27/L-Lactate Dehydrogenase; EC 2.6.1.1/Aspartate Aminotransferases; EC 2.6.1.2/Alanine Transaminase; EC 2.7.3.2/Creatine Kinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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