Document Detail


Enzymatic adaptations to treadmill training under the influence of naftidrofuryl acid in diaphragm and limb muscles of old rats.
MedLine Citation:
PMID:  1713485     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of training and naftidrofuryl treatment were observed in 21-month-old Long-Evans rats. Rats were injected intraperitoneally twice daily for 8 weeks with 7 mg.kg-1 of naftidrofuryl acid (SN, TN), or with 7 mg.kg-1 fumaric acid (SC and TC) or used as solvent. Training groups (TC, TN) started a progressive 8-week training programme of treadmill exercise. The activities of lactate dehydrogenase (LDH), hexokinase (HK), citrate synthase (CS) and 3-hydroxyacyl-Co-A-dehydrogenase (HAD), were measured in Soleus (SOL), Extensor Digitorum Longus (EDL) and Diaphragm (DIA) muscles. The mean VO2max value was 65 ml.min-1.kg-1 for 21-month-old rats. The training protocol induced increases in the mean VO2max values in the TC and TN groups, 71.8 and 74.4 ml.min-1.kg-1. In sedentary groups (SN), naftidrofuryl increased enzymatic activities (HK, CS, HAD) in the three muscles examined. When the animals underwent 8 weeks of physical training, the enzymatic activities (HK, CS, HAD) increased in SOL, EDL and DIA. When training was combined with naftidrofuryl treatment the increases in enzymatic activities were greater than those induced by training alone. However, the total changes did not differ for the sum of the changes produced by each condition alone.
Authors:
J Sanchez; A M Sarue; A Brunet; H Monod
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives internationales de physiologie, de biochimie et de biophysique     Volume:  99     ISSN:  0778-3124     ISO Abbreviation:  Arch Int Physiol Biochim Biophys     Publication Date:  1991 Feb 
Date Detail:
Created Date:  1991-08-30     Completed Date:  1991-08-30     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9111069     Medline TA:  Arch Int Physiol Biochim Biophys     Country:  BELGIUM    
Other Details:
Languages:  eng     Pagination:  129-34     Citation Subset:  IM; S    
Affiliation:
Laboratoire de Physiologie du Travail-UA 385-CNRS, Faculté de Médecine, Pitié-Salpêtrière, Université Pierre et Marie Curie, Paris, France.
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MeSH Terms
Descriptor/Qualifier:
3-Hydroxyacyl CoA Dehydrogenases / metabolism
Aging / metabolism*
Animals
Body Weight
Citrate (si)-Synthase / metabolism
Diaphragm / drug effects,  enzymology
Hexokinase / metabolism
L-Lactate Dehydrogenase / metabolism
Muscles / drug effects,  enzymology*
Nafronyl / pharmacology*
Physical Conditioning, Animal*
Physical Exertion / physiology
Rats
Chemical
Reg. No./Substance:
31329-57-4/Nafronyl; EC 1.1.1.27/L-Lactate Dehydrogenase; EC 1.1.1.35/3-Hydroxyacyl CoA Dehydrogenases; EC 2.3.3.1/Citrate (si)-Synthase; EC 2.7.1.1/Hexokinase

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