Document Detail


Environmentally relevant concentrations of ammonium perchlorate inhibit development and metamorphosis in Xenopus laevis.
MedLine Citation:
PMID:  11833812     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We determined whether environmentally relevant concentrations of ammonium perchlorate alter development and metamorphosis in Xenopus laevis. Eggs and larvae were exposed to varying concentrations of ammonium perchlorate or control medium for 70 d. Most treatment-related mortality was observed within 5 d after exposure and was due in large part to reduced hatching success. The 5- and 70-d median lethal concentrations (LC50s) were 510 +/- 36 mg ammonium perchlorate/L and 223 +/- 13 mg ammonium perchlorate/L, respectively. Ammonium perchlorate did not cause any concentration-related developmental abnormalities at concentrations below the 70-d LC50. Ammonium perchlorate inhibited metamorphosis in a concentration-dependent manner as evident from effects on forelimb emergence, tail resorption, and hindlimb growth. These effects were observed after exposure to ammonium perchlorate concentrations in the parts-per-billion range, at or below concentrations reported in surface waters contaminated with ammonium perchlorate. Ammonium perchlorate significantly inhibited tail resorption after a 14-d exposure in the U.S. Environmental Protection Agency (U.S. EPA) Endocrine Disruptor Screening and Testing Committee (EDSTAC) Tier I frog metamorphosis assay for thyroid disruption in amphibians. We believe that ammonium perchlorate may pose a threat to normal development and growth in natural amphibian populations.
Authors:
Wanda L Goleman; Lina J Urquidi; Todd A Anderson; Ernest E Smith; Ronald J Kendall; James A Carr
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Environmental toxicology and chemistry / SETAC     Volume:  21     ISSN:  0730-7268     ISO Abbreviation:  Environ. Toxicol. Chem.     Publication Date:  2002 Feb 
Date Detail:
Created Date:  2002-02-08     Completed Date:  2002-02-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8308958     Medline TA:  Environ Toxicol Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  424-30     Citation Subset:  IM    
Affiliation:
Department of Biological Sciences, Texas Tech University, Lubbock 79409, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Dose-Response Relationship, Drug
Forelimb / growth & development
Hindlimb / growth & development
Lethal Dose 50
Metamorphosis, Biological / drug effects*
Perchloric Acid / adverse effects*
Quaternary Ammonium Compounds / adverse effects*
Tail / growth & development
Water Pollutants, Chemical / adverse effects*
Xenopus laevis / growth & development
Chemical
Reg. No./Substance:
0/Quaternary Ammonium Compounds; 0/Water Pollutants, Chemical; 7601-90-3/Perchloric Acid; 7790-98-9/ammonium perchlorate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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