| Environmentally relevant concentrations of ammonium perchlorate inhibit development and metamorphosis in Xenopus laevis. | |
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MedLine Citation:
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PMID: 11833812 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We determined whether environmentally relevant concentrations of ammonium perchlorate alter development and metamorphosis in Xenopus laevis. Eggs and larvae were exposed to varying concentrations of ammonium perchlorate or control medium for 70 d. Most treatment-related mortality was observed within 5 d after exposure and was due in large part to reduced hatching success. The 5- and 70-d median lethal concentrations (LC50s) were 510 +/- 36 mg ammonium perchlorate/L and 223 +/- 13 mg ammonium perchlorate/L, respectively. Ammonium perchlorate did not cause any concentration-related developmental abnormalities at concentrations below the 70-d LC50. Ammonium perchlorate inhibited metamorphosis in a concentration-dependent manner as evident from effects on forelimb emergence, tail resorption, and hindlimb growth. These effects were observed after exposure to ammonium perchlorate concentrations in the parts-per-billion range, at or below concentrations reported in surface waters contaminated with ammonium perchlorate. Ammonium perchlorate significantly inhibited tail resorption after a 14-d exposure in the U.S. Environmental Protection Agency (U.S. EPA) Endocrine Disruptor Screening and Testing Committee (EDSTAC) Tier I frog metamorphosis assay for thyroid disruption in amphibians. We believe that ammonium perchlorate may pose a threat to normal development and growth in natural amphibian populations. |
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Authors:
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Wanda L Goleman; Lina J Urquidi; Todd A Anderson; Ernest E Smith; Ronald J Kendall; James A Carr |
Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Environmental toxicology and chemistry / SETAC Volume: 21 ISSN: 0730-7268 ISO Abbreviation: Environ. Toxicol. Chem. Publication Date: 2002 Feb |
Date Detail:
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Created Date: 2002-02-08 Completed Date: 2002-02-20 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8308958 Medline TA: Environ Toxicol Chem Country: United States |
Other Details:
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Languages: eng Pagination: 424-30 Citation Subset: IM |
Affiliation:
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Department of Biological Sciences, Texas Tech University, Lubbock 79409, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Dose-Response Relationship, Drug Forelimb / growth & development Hindlimb / growth & development Lethal Dose 50 Metamorphosis, Biological / drug effects* Perchloric Acid / adverse effects* Quaternary Ammonium Compounds / adverse effects* Tail / growth & development Water Pollutants, Chemical / adverse effects* Xenopus laevis / growth & development |
| Chemical | |
Reg. No./Substance:
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0/Quaternary Ammonium Compounds; 0/Water Pollutants, Chemical; 7601-90-3/Perchloric Acid; 7790-98-9/ammonium perchlorate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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