Document Detail


Environmental toxicants--induced epigenetic alterations and their reversers.
MedLine Citation:
PMID:  23167630     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Epigenetics has been emphasized in the postgenome era to clarify obscure health risks of environmental toxicants including endocrine disrupting chemicals (EDCs). In addition, mixed exposure in real life can modify health consequences of the toxicants. Particularly, some nutritional and dietary materials modify individual susceptibility through changes in the epigenome. Therefore, we focused on some environmental toxicants that induce epigenetic alterations, and introduced chemopreventive materials to reverse the toxicants-induced epigenetic alterations. Methodologically, we used global and specific DNA methylation as epigenetic end points and searched epigenetic modulators in food. We reviewed various epigenetic end points induced by environmental toxicants including alcohol, asbestos, nanomaterials, benzene, EDCs, metals, and ionizing radiation. The epigenetic end points can be summarized into global hypomethylation and specific hypermethylation at diverse tumor suppress genes. Exposure timing, dose, sex, or organ specificity should be considered to use the epigenetic end points as biomarkers for exposure to the epimutagenic toxicants. Particularly, neonatal exposure to the epimutagens can influence their future adult health because of characteristics of the epimutagens, which disrupt epigenetic regulation in imprinting, organogenesis, development, etc. Considering interaction between epimutagenic toxicants and their reversers in food, we suggest that multiple exposures to them can alleviate or mask epigenetic toxicity in real life. Our present review provides useful information to find new end points of environmental toxicants and to prevention from environment-related diseases.
Authors:
Minju Kim; Minji Bae; Hyunkyung Na; Mihi Yang
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Journal of environmental science and health. Part C, Environmental carcinogenesis & ecotoxicology reviews     Volume:  30     ISSN:  1532-4095     ISO Abbreviation:  J Environ Sci Health C Environ Carcinog Ecotoxicol Rev     Publication Date:  2012  
Date Detail:
Created Date:  2012-11-21     Completed Date:  2013-04-12     Revised Date:  2013-11-06    
Medline Journal Info:
Nlm Unique ID:  9317093     Medline TA:  J Environ Sci Health C Environ Carcinog Ecotoxicol Rev     Country:  England    
Other Details:
Languages:  eng     Pagination:  323-67     Citation Subset:  IM    
Affiliation:
Research Center for Cell Fate Control, College of Pharmacy, Sookmyung Women's University, Yongsan-gu, Seoul, Republic of Korea.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antimutagenic Agents / therapeutic use*
Biological Markers / analysis
DNA Methylation / drug effects,  radiation effects
Environmental Exposure*
Environmental Pollutants / toxicity
Epigenesis, Genetic / drug effects*,  radiation effects*
Genes, Tumor Suppressor / drug effects,  radiation effects
Humans
Mice
Mutagens / toxicity*
Radiation Injuries*
Radiation, Ionizing*
Rats
Chemical
Reg. No./Substance:
0/Antimutagenic Agents; 0/Biological Markers; 0/Environmental Pollutants; 0/Mutagens
Comments/Corrections
Erratum In:
J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2013;31(3):285

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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